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首页> 外文期刊>Journal of neuro-ophthalmology: Official journal of the North American Neuro-Ophthalmology Society >Shortened Pattern Electroretinogram Latency and Impaired Autoregulatory Dynamics to Steady-State Stimuli in Patients With Multiple Sclerosis
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Shortened Pattern Electroretinogram Latency and Impaired Autoregulatory Dynamics to Steady-State Stimuli in Patients With Multiple Sclerosis

机译：缩短图案电气图曲线延迟，多发性硬化症患者稳态刺激的自动调节动力学

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Background: The steady-state pattern electroretinogram (PERG) is a sensitive measure of retinal ganglion cell (RGC) function that includes within-test progressive changes-adaptation-reflecting RGC autoregulatory dynamics. Comprehensive PERG assessment in patients with multiple sclerosis (MS) (with or without optic neuritis [ON]) may provide unique information about RGC dysfunction and its progression, as well as a comparison between functional loss and structural loss as measured by optical coherence tomography (OCT). The goal of this project was to measure steady-state PERG components and their associations with intraretinal layer thicknesses in MS. Methods: One hundred forty eyes of 70 patients with relapsing-remitting MS and 126 eyes of 63 age- and sex-matched healthy control subjects (HC) were investigated using a new-generation PERG method and ultrahigh-resolution OCT. Of MS eyes, there were 30 eyes with ON (MSON), 22 non-ON fellow eyes (MSFE), and 88 non-ON MS eyes (MSNON). PERG amplitude, phase (latency), and adaptation of amplitude and phase were measured and correlated with OCT-determined thicknesses of intraretinal layers. Results: The average PERG amplitude in MSON eyes was significantly lower than MSFE (P = 0.007), MSNON (P = 0.002), and HC (P 0.05). PERG adaptation of amplitude in MSON was significantly lower than that in MSNON (P = 0.039) and HC (P = 0.037). Both the amplitude and latency in the MS eyes were significantly correlated with the thicknesses of the macular retinal nerve fiber layer (mRNFL) and ganglion cell-inner plexiform layer (GCIPL). Conclusions: Shortened PERG latency and impaired autoregulatory dynamics occurred in MS, suggesting preferential dysfunction of small, slower RGC axons and decreased ability of RGC to autoregulate their gain in response to PERG stimulus. The established relations of PERG measurements with intraretinal thickness measurements suggested that PERG losses were primarily associated with GCIPL and mRNFL thinning.
机译：背景：稳态模式视网膜电图（PERG）是对视网膜神经节细胞（RGC）功能的敏感测量，包括反映RGC自动调节动力学的测试内进行性变化适应。对多发性硬化（MS）患者（有或无视神经炎[ON]）进行全面的PERG评估，可以提供有关RGC功能障碍及其进展的独特信息，以及通过光学相干断层扫描（OCT）测量的功能丧失和结构丧失之间的比较。本项目的目标是测量稳态PERG成分及其与MS视网膜内层厚度的关系。方法：采用新一代PERG方法和MS眼超高分辨率OCT，对70例复发缓解型MS患者的140只眼和63例年龄和性别匹配的健康对照者（HC）的126只眼进行调查，其中30只眼为开（MSON），22只眼为非开（MSFE），88只眼为非开（MSNON）。测量PERG振幅、相位（潜伏期）以及振幅和相位的适应性，并与OCT确定的视网膜内层厚度相关。结果：MSON眼的平均PERG振幅显著低于MSFE（P=0.007）、MSNON（P=0.002）和HC（P=0.05）。MSON组的PERG振幅适应性显著低于MSNON组（P=0.039）和HC组（P=0.037）。MS眼的振幅和潜伏期均与黄斑视网膜神经纤维层（mRNFL）和神经节细胞内丛状层（GCIPL）的厚度显著相关。结论：MS患者出现PERG潜伏期缩短和自动调节动力学受损，提示小而慢的RGC轴突优先功能障碍，RGC对PERG刺激的自动调节增益能力降低。已建立的PERG测量与视网膜内厚度测量之间的关系表明，PERG损失主要与GCIPL和mRNFL变薄有关。

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