Involvement and relationship of bacterial lipopolysaccharides and cyclooxygenases levels in Alzheimer's Disease and Mild Cognitive Impairment patients

Andreadou Eleni G.; Katsipis Georgios; Tsolaki Magda; Pantazaki Anastasia A.

首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Involvement and relationship of bacterial lipopolysaccharides and cyclooxygenases levels in Alzheimer's Disease and Mild Cognitive Impairment patients

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Involvement and relationship of bacterial lipopolysaccharides and cyclooxygenases levels in Alzheimer's Disease and Mild Cognitive Impairment patients

机译：细菌脂多糖和萘氧基酶水平在阿尔茨海默病和轻度认知障碍患者中的参与和关系

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This study reports elevated levels of bacterial lipopolysaccharides (LPSs) and cyclooxygenases (COX-1/2) in blood serum and cerebrospinal fluid (CSF) of Alzheimer's Disease (AD) and Mild Cognitive Impairment (MCI) patients compared to cognitively healthy individuals, indicating LPSs as promising biomarkers, especially in serum. LPSs, in both fluids, positively correlate with COX-1/2, A beta 42 and tau and negatively with mental state. Furthermore, COX-2 is the main determinant of LPSs presence in serum, whereas COX-1 in CSF. These results underline the significance of microbial/ inflammatory involvement in dementia and offer novel perspectives on the roles of LPSs and COX in pathogenesis of AD.

机译：本研究报告，与认知健康个体相比，阿尔茨海默病（AD）和轻度认知障碍（MCI）患者的血清和脑脊液（CSF）中细菌脂多糖（LPSs）和环氧化酶（COX-1/2）水平升高，表明LPSs是一种有希望的生物标记物，尤其是在血清中。两种体液中的LPSs与COX-1/2、Aβ42和tau呈正相关，与精神状态呈负相关。此外，COX-2是LPSs在血清中存在的主要决定因素，而COX-1在CSF中存在。这些结果强调了微生物/炎症参与痴呆的重要性，并为LPSs和COX在AD发病机制中的作用提供了新的视角。

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来源
《Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology》 |2021年第1期|共13页
作者
Andreadou Eleni G.; Katsipis Georgios; Tsolaki Magda; Pantazaki Anastasia A.;
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作者单位

Aristotle Univ Thessaloniki Dept Chem Lab Biochem Thessaloniki 54124 Greece;

Aristotle Univ Thessaloniki Dept Chem Lab Biochem Thessaloniki 54124 Greece;

Aristotle Univ Thessaloniki AHEPA Univ Gen Hosp Thessaloniki Neurol Dept 1 Thessaloniki 54124;

Aristotle Univ Thessaloniki Dept Chem Lab Biochem Thessaloniki 54124 Greece;

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原文格式 PDF
正文语种 eng
中图分类神经病学;
关键词
Biomarkers; Alzheimer's Disease; Mild Cognitive Impairment; Lipopolysaccharides; Cyclooxygenases; Inflammation;

机译：生物标志物;阿尔茨海默病;轻度认知障碍;脂多糖;环氧化酶;发炎;

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Involvement and relationship of bacterial lipopolysaccharides and cyclooxygenases levels in Alzheimer's Disease and Mild Cognitive Impairment patients

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