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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Crosstalk between gut microbiome and immunology in the management of ischemic brain injury
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Crosstalk between gut microbiome and immunology in the management of ischemic brain injury

机译：肠道微生物组和免疫学之间的串扰在缺血性脑损伤管理之间

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Ischemic brain injury is a serious neurological complication, which accrues an immense activation of neuroinflammatory responses. Several lines of research suggested the interconnection of gut microbiota perturbation with the activation of proinflammatory mediators. Intestinal microbial communities also interchange information with the brain through various afferent and efferent channels and microbial by-products. Herein, we discuss the different microelements of gut microbiota and its connection with the host immune system and how change in immune-microbial signatures correlates with the stroke incidence and post-injury neurological sequelae. The activated inflammatory cells increase the production of proinflammatory cytokines, chemokines, proteases and adhesive proteins that are involved in the systemic inflammation, blood brain barrier disruption, gut dysbiosis and aggravation of ischemic brain injury. We suggest that fine-tuning of commensal gut microbiota (eubiosis) may regulate the activation of CNS resident cells like microglial, astrocytes, mast cells and natural killer cells.
机译：缺血性脑损伤是一种严重的神经系统并发症，引起神经炎症反应的强烈激活。几项研究表明，肠道微生物群的扰动与促炎症介质的激活相互关联。肠道微生物群落还通过各种传入和传出通道以及微生物副产物与大脑交换信息。在此，我们讨论了肠道微生物群的不同微量元素及其与宿主免疫系统的关系，以及免疫微生物特征的变化如何与中风发病率和损伤后神经后遗症相关。活化的炎性细胞增加促炎细胞因子、趋化因子、蛋白酶和粘附蛋白的产生，它们参与全身炎症、血脑屏障破坏、肠道失调和缺血性脑损伤的加重。我们认为，微调共生肠道菌群（优生）可能会调节中枢神经系统驻留细胞（如小胶质细胞、星形胶质细胞、肥大细胞和自然杀伤细胞）的激活。

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