Modeling compartmentalized chronic immune-mediated demyelinating CNS disease in the Biozzi ABH mouse

Nishri Yossi; Fainstein Nina; Goldfarb Smadar; Hampton David; Macrini Caterina; Meinl Edgar; Chandran Siddharthan; Ben-Hur Tamir

首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Modeling compartmentalized chronic immune-mediated demyelinating CNS disease in the Biozzi ABH mouse

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Modeling compartmentalized chronic immune-mediated demyelinating CNS disease in the Biozzi ABH mouse

机译：在生物动物ABH小鼠中建模分区慢性免疫免疫介导的脱髓鞘CNS病

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摘要

We explored whether experimental autoimmune encephalomyelitis (EAE) in Biozzi mice recapitulates temporal dynamics of tissue injury, immune-pathogenesis and CNS compartmentalization occurring in progressive multiple sclerosis (MS). Chronic EAE exhibited relapsing and progressing disease, partial closure of BBB, reduced tissue inflammatory activity, and development of meningeal ectopic lymphoid tissue, directly opposing (potentially driving) spinal subpial demyelinated plaques. A T cell predominant disease during relapses transformed into a B cell predominant disease in late chronic EAE, with high serum anti-MOG reactivity. Thus, late chronic Biozzi EAE recapitulates essential features of progressive MS, and is suitable for developing disease modifying and regenerative therapies.

机译：我们探讨了Biozzi小鼠实验性自身免疫性脑脊髓炎（EAE）是否再现了进行性多发性硬化（MS）中组织损伤、免疫发病机制和CNS区隔化的时间动力学。慢性EAE表现为疾病复发和进展，BBB部分闭合，组织炎症活动减少，脑膜异位淋巴组织发育，直接对抗（潜在驱动）脊髓膜下脱髓鞘斑块。在晚期慢性EAE中，复发期间的T细胞优势疾病转变为B细胞优势疾病，具有高血清抗MOG反应性。因此，晚期慢性Biozzi EAE概括了进行性MS的基本特征，适合开发疾病改良和再生疗法。

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来源
《Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology》 |2021年第1期|共12页
作者
Nishri Yossi; Fainstein Nina; Goldfarb Smadar; Hampton David; Macrini Caterina; Meinl Edgar; Chandran Siddharthan; Ben-Hur Tamir;
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作者单位

Hebrew Univ Jerusalem Fac Med Jerusalem Israel;

Hebrew Univ Jerusalem Fac Med Jerusalem Israel;

Hebrew Univ Jerusalem Fac Med Jerusalem Israel;

Univ Edinburgh Ctr Clin Brain Sci MS Ctr Edinburgh Midlothian Scotland;

Ludwig Maximilians Univ Munchen Inst Clin Neuroimmunol Biomed Ctr Munich Germany;

Ludwig Maximilians Univ Munchen Inst Clin Neuroimmunol Biomed Ctr Munich Germany;

Univ Edinburgh Ctr Clin Brain Sci MS Ctr Edinburgh Midlothian Scotland;

Hebrew Univ Jerusalem Fac Med Jerusalem Israel;

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原文格式 PDF
正文语种 eng
中图分类神经病学;
关键词
Progressive multiple sclerosis; Experimental autoimmune encephalomyelitis; Demyelination; Animal model;

机译：进行性多发性硬化症;实验性自身免疫性脑脊髓炎;脱髓鞘;动物模型;

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Modeling compartmentalized chronic immune-mediated demyelinating CNS disease in the Biozzi ABH mouse

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