Isolated CNS involvement in eosinophilic granulomatosis with polyangiitis treated with mepolizumab: A case report

Son Hyoshin; Lee Woo-Jin; Moon Jangsup; Yoon Sungjoon; Jung Keun-Hwa; Park Kyung-Il; Lee Sang Kun; Chu Kon

首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Isolated CNS involvement in eosinophilic granulomatosis with polyangiitis treated with mepolizumab: A case report

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Isolated CNS involvement in eosinophilic granulomatosis with polyangiitis treated with mepolizumab: A case report

机译：孤立的CNS参与含有Mepolizumab的多苯炎的嗜酸性粒细胞芽孢杆菌：案例报告

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摘要

Eosinophilic granulomatosis with polyangiitis (EGPA) is a systemic vasculitis disease involving small-sized vessels. The literature has reported involvement of the central nervous system (CNS) in 5% cases, and isolated CNS involvement is extremely rare. Due to its rarity and scarcity of clinical data, standardized treatment of isolated CNS involvement in EGPA is unclear. Mepolizumab, an anti-interleukin-5 monoclonal antibody, was previously introduced to treat EGPA with longer remission period, more patients showing remission, and reduction in prednisolone dose of those who already taking prednisolone compared to placebo. We describe a case of isolated CNS involvement in EGPA, confirmed by brain biopsy and treated with mepolizumab, which was refractory to conventional immunotherapy.

机译：嗜酸性肉芽肿伴多血管炎（EGPA）是一种涉及小血管的系统性血管炎疾病。文献报道有5%的病例累及中枢神经系统（CNS），孤立的CNS累及极为罕见。由于临床数据稀少，EGPA孤立性中枢神经系统受累的标准化治疗尚不清楚。美波利珠单抗是一种抗白细胞介素-5的单克隆抗体，以前被用于治疗EGPA，其缓解期更长，出现缓解的患者更多，与安慰剂相比，已经服用泼尼松龙的患者的泼尼松龙剂量减少。我们描述了一例EGPA中孤立性中枢神经系统受累的病例，经脑活检证实，并用常规免疫治疗无效的美波利珠单抗治疗。

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来源
《Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology》 |2021年第1期|共4页
作者
Son Hyoshin; Lee Woo-Jin; Moon Jangsup; Yoon Sungjoon; Jung Keun-Hwa; Park Kyung-Il; Lee Sang Kun; Chu Kon;
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作者单位

Seoul Natl Univ Hosp Dept Neurol 101 Daehak Ro Seoul 110744 South Korea;

Seoul Natl Univ Hosp Dept Neurol 101 Daehak Ro Seoul 110744 South Korea;

Seoul Natl Univ Hosp Dept Neurol 101 Daehak Ro Seoul 110744 South Korea;

Seoul Natl Univ Hosp Dept Neurol 101 Daehak Ro Seoul 110744 South Korea;

Seoul Natl Univ Hosp Dept Neurol 101 Daehak Ro Seoul 110744 South Korea;

Seoul Natl Univ Hosp Healthcare Syst Dept Neurol Gangnam Ctr Seoul South Korea;

Seoul Natl Univ Hosp Dept Neurol 101 Daehak Ro Seoul 110744 South Korea;

Seoul Natl Univ Hosp Dept Neurol 101 Daehak Ro Seoul 110744 South Korea;

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原文格式 PDF
正文语种 eng
中图分类神经病学;
关键词
Central nervous system (CNS); Anti-interleukin-5 antibody; Mepolizumab; Brain biopsy; Eosinophilic granulomatosis with polyangiitis (EGPA);

机译：中枢神经系统;抗白细胞介素-5抗体;Mepolizumab;脑活检;嗜酸性肉芽肿伴多血管炎（EGPA）;

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2. Refractory diffuse alveolar hemorrhage caused by eosinophilic granulomatosis with polyangiitis in the absence of elevated biomarkers treated successfully by rituximab and mepolizumab: A case report [J] . Akihiro Shiroshita, Kei Nakashima, Shinji Motojima, Respiratory Medicine Case Reports . 2019,第1期

机译：利妥昔单抗和美泊珠单抗成功治疗后，在缺乏升高的生物标志物的情况下，由嗜酸性粒细胞肉芽肿合并多血管炎引起的难治性弥漫性肺泡出血：一例报告
3. Concurrent Use of Mepolizumab and Rituximab for Eosinophilic Granulomatosis With Polyangiitis and Multisystem Involvement [J] . Agura Afiari, Andre Gabriel, Meghana R. Gaiki Cureus. . 2020,第7期

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4. Early add-on administration of mepolizumab and intravenous immunoglobulin effective in treating eosinophilic granulomatosis with polyangiitis [J] . Ikeda Takaharu, Komatsu Toshiro, Yokoyama Kae, The Journal of dermatology . 2021,第4期

机译：早期加入施用Mepolizumab和静脉注射免疫球蛋白，有效治疗嗜酸性粒细胞粒细胞芽孢杆菌
5. A case report of Granulomatous polyangiitis [C] . Nan Li, Mo Sun, Yanhua Li, International Conference on Information Technology in Medicine and Education . 2018

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7. Refractory diffuse alveolar hemorrhage caused by eosinophilic granulomatosis with polyangiitis in the absence of elevated biomarkers treated successfully by rituximab and mepolizumab: A case report [O] . Akihiro Shiroshita, Kei Nakashima, Shinji Motojima, 2019

机译：利妥昔单抗和美泊珠单抗成功治疗后在缺乏升高的生物标志物的情况下由嗜酸性粒细胞肉芽肿合并多血管炎引起的难治性弥漫性肺泡出血：一例报告
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机译：难治性弥漫性肺泡出血引起的嗜酸性粒细胞瘤引起的嗜酸性粒细胞炎，在没有Rituximab和Mepolizumab成功治疗的升高的生物标志物的情况下，案例报告
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机译：基质分离CN（ - ）分子的振动斯塔克效应。（重新公布新的可用性信息）

Isolated CNS involvement in eosinophilic granulomatosis with polyangiitis treated with mepolizumab: A case report

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