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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Serum ADMA levels were positively correlated with EDSS scores in patients with multiple sclerosis
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Serum ADMA levels were positively correlated with EDSS scores in patients with multiple sclerosis

机译：血清ADMA水平与多发性硬化症患者的EDSS分数呈正相关

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摘要

Multiple sclerosis (MS) is an autoinflammatory, chronic central nervous system disease. In the pathogenesis of the disease increased nitric oxide (NO) levels play an important role. Nitric oxide (NO) has neuroprotective effects in physiological conditions, however, it is thought that excessive NO formation in MS may lead to demyelination and axonal damage. Derivatives of methylarginine including asymmetric dimethyl arginine (ADMA), L-N monomethyl arginine (L-NMMA), symmetric dimethyl arginine (SDMA) directly or indirectly reduce NO production. Our aim was to measure the levels of methylarginine derivatives and citrulline, ornithine, arginine, homoarginine levels, which are metabolites associated with NO metabolism, in MS subgroups.
机译：多发性硬化症（MS）是一种自身炎症性慢性中枢神经系统疾病。在疾病的发病机制中，一氧化氮（NO）水平升高起着重要作用。一氧化氮（NO）在生理条件下具有神经保护作用，然而，人们认为MS中过量NO的形成可能导致脱髓鞘和轴突损伤。甲基精氨酸衍生物包括不对称二甲基精氨酸（ADMA）、L-N单甲基精氨酸（L-NMMA）、对称二甲基精氨酸（SDMA）直接或间接减少NO生成。我们的目的是测量MS亚组中甲基精氨酸衍生物和瓜氨酸、鸟氨酸、精氨酸、高精氨酸的水平，它们是与NO代谢相关的代谢物。

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