LncRNA NEAT1/miR-128-3p/AQP4 axis regulating spinal cord injury-induced neuropathic pain progression

Xian Shuyue; Ding Ruiwen; Li Mengyun; Chen Feng

首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >LncRNA NEAT1/miR-128-3p/AQP4 axis regulating spinal cord injury-induced neuropathic pain progression

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LncRNA NEAT1/miR-128-3p/AQP4 axis regulating spinal cord injury-induced neuropathic pain progression

机译：LNCRNA Neat1 / miR-128-3P / AQP4轴调节脊髓损伤诱导的神经病疼痛进展

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Background: Neuropathic pain (NP) is the comorbidity in spinal cord injury(SCI), which is the hardest to cure. Non-coding RNA dysregulations are related to the development of NP. NEAT1(nuclear paraspeckle assembly transcript 1) is a new type of lncRNA. This study explores the role and specific mechanism of NEAT1 in SCI-mediated NP.

机译：背景：神经病理性疼痛（NP）是脊髓损伤（SCI）中最难治愈的共病。非编码RNA失调与NP的发展有关。NEAT1是一种新型的lncRNA。本研究探讨NEAT1在SCI介导的NP中的作用及其具体机制。

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来源
《Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology》 |2021年第1期|共10页
作者
Xian Shuyue; Ding Ruiwen; Li Mengyun; Chen Feng;
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作者单位

Wuhan Univ Dept Anesthesiol Zhongnan Hosp 169 Donghu Rd Wuhan 430071 Hubei Peoples R China;

Wuhan Univ Dept Anesthesiol Zhongnan Hosp 169 Donghu Rd Wuhan 430071 Hubei Peoples R China;

Wuhan Univ Dept Anesthesiol Zhongnan Hosp 169 Donghu Rd Wuhan 430071 Hubei Peoples R China;

Wuhan Univ Dept Anesthesiol Zhongnan Hosp 169 Donghu Rd Wuhan 430071 Hubei Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类神经病学;
关键词
Spinal cord injury; Neuropathic pain; NEAT1; miR-128-3p; AQP4;

机译：脊髓损伤;神经病理性疼痛;NEAT1;miR-128-3p;AQP4;

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专利

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2. Proteomic analysis of the dorsal spinal cord in the mouse model of spared nerve injury-induced neuropathic pain [J] . Eun-sung Park, Jung-mo Ahn, Sang-min Jeon, 生物医学研究杂志：英文版 . 2017,第006期
3. Activation of ERK/CREB pathway in spinal cord contributes to chronic constrictive injury-induced neuropathic pain in rats [J] . Xue-song SONG, Jun-li CAO, Yan-bing XU, 中国药理学报：英文版 . 2005,第007期
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机译：脊髓背钙通道α-2-delta-1蛋白上调介导脊髓损伤引起的神经性疼痛状态。
6. LncRNA SNHG1 attenuates neuropathic pain following spinal cord injury by regulating CDK4 level [J] . J.-Y. Zhang, D.-B. Lv, Y.-N. Su, European review for medical and pharmacological sciences. . 2020,第23期

机译：LNCRNA SNHG1通过调节CDK4水平，通过调节脊髓损伤后衰减神经疗法疼痛
7. LncRNA MIAT facilitates osteosarcoma progression by regulating mir-128-3p/VEGFC axis [J] . Zhang Chunyan, Xie Linsen, Liang Huiling, IUBMB life . 2019,第7期

机译：LncraNa Miat通过调节MiR-128-3P / VEGFC轴来促进骨肉瘤进展
8. Tri-wave laser therapy for spinal cord injury, neuropathic pain management, and restoration of motor function [C] . Mark D. Chariff, Peter Olszak Mechanisms for low-light therapy X . 2015

机译：三波激光疗法可治疗脊髓损伤，神经性疼痛和恢复运动功能
9. A conditional deletion of the GluR2 subunit of the AMPA receptor in adult spinal cord dorsal horn decreases normal sensory thresholds but not injury-induced pain. [D] . Hegarty, Deborah Mary. 2006

机译：成年脊髓背角中AMPA受体的GluR2亚基的有条件删除会降低正常的感觉阈值，但不会导致损伤引起的疼痛。
10. LncRNA MIR4435-2HG triggers ovarian cancer progression by regulating miR-128-3p/CKD14 axis [O] . Lijuan Zhu, Aihua Wang, Mei Gao, 2020

机译：LncRNA MIR4435-2HG通过调节miR-128-3p / CKD14轴触发卵巢癌进展
11. NEAT1 siRNA Packed with Chitosan Nanoparticles Regulates the Development of Colon Cancer Cells via lncRNA NEAT1/miR-377-3p Axis [O] . Tianyu Li, Nenghui Deng, Ruimei Xu, 2021

机译：用壳聚糖纳米粒子包装的Neat1 siRNA通过LNCRNA Neat1 / miR-377-3P轴调节结肠癌细胞的发育
12. Modulation of Invading and Resident Inflammatory Cell Activation as a Novel Way to Mitigate Spinal Cord Injury-Associated Neuropathic Pain. [R] . Ward, S. J. 2017

机译：调节侵袭和常驻炎症细胞活化作为减轻脊髓损伤相关神经性疼痛的新方法。

LncRNA NEAT1/miR-128-3p/AQP4 axis regulating spinal cord injury-induced neuropathic pain progression

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