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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >How subtle differences in polymer molecular weight affect doxorubicin-loaded PLGA nanoparticles degradation and drug release
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How subtle differences in polymer molecular weight affect doxorubicin-loaded PLGA nanoparticles degradation and drug release

机译：多种聚合物分子量的微妙差异影响多柔比蛋白加载的PLGA纳米粒子降解和药物释放

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Aims: To evaluate the influence of minor differences in molecular weights of commercially available low molecular weight PLGA grades on the kinetics of doxorubicin release from the nanoparticles. Methods: Three low-molecular weight 50/50 PLGA polymers were thoroughly characterised concerning intrinsic viscosity, molecular weight (Mw), acid value, and residual monomer content. The doxorubicin-loaded nanoparticles prepared using these polymers were evaluated concerning the kinetics of drug release and hydrolytic degradation. Results: The Mw of the polymers were slightly different: 10.2, 10.3, and 4.7 kDa. The nanoparticles obtained from the polymer with Mw of 4.7 kDa exhibited considerably higher rates of drug release and polymer degradation. Conclusion: In the case of low molecular weight PLGA grades even a few kilodaltons could be important for the batch-to-batch reproducibility of the nanoformulation parameters. These results bring forward the importance of in-house characterisation of the polymers to be used for the nanoparticle preparation.
机译：目的：评估商用低分子量PLGA等级的分子量微小差异对阿霉素从纳米颗粒释放动力学的影响。方法：对三种低分子量50/50 PLGA聚合物的特性粘度、分子量（Mw）、酸值和残余单体含量进行了全面表征。利用这些聚合物制备的阿霉素纳米粒在药物释放和水解降解动力学方面进行了评估。结果：聚合物的分子量略有不同：10.2、10.3和4.7kDa。从分子量为4.7 kDa的聚合物中获得的纳米颗粒显示出相当高的药物释放率和聚合物降解率。结论：在低分子量PLGA等级的情况下，即使是几千道尔顿也可能对纳米配方参数的批间重现性很重要。这些结果提出了用于纳米颗粒制备的聚合物内部表征的重要性。

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