...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Thermo-responsive magnetic liposomes for hyperthermia-triggered local drug delivery
【24h】

Thermo-responsive magnetic liposomes for hyperthermia-triggered local drug delivery

机译：热响应磁性脂质体，用于热疗引发的局部药物递送

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We prepared and characterised thermo-responsive magnetic liposomes, which were designed to combine features of magnetic targeting and thermo-responsive control release for hyperthermia-triggered local drug delivery. The particle size and zeta-potential of the thermo-responsive magnetic ammonium bicarbonate (MagABC) liposomes were about 210nm and -14mV, respectively. The MagABC liposomes showed encapsulation efficiencies of about 15% and 82% for magnetic nanoparticles (mean crystallite size 12nm) and doxorubicin (DOX), respectively. The morphology of the MagABC liposomes was visualised using transmission electron microscope (TEM). The MagABC liposomes showed desired thermo-responsive release. The MagABC liposomes, when physically targeted to tumour cells in culture by a permanent magnetic field yielded a substantial increase in intracellular accumulation of DOX as compared to non-magnetic ammonium bicarbonate (ABC) liposomes. This resulted in a parallel increase in cytotoxicity for DOX loaded MagABC liposomes over DOX loaded ABC liposomes in tumour cells.
机译：我们制备并表征了热响应磁性脂质体，其设计结合了磁靶向和热响应控制释放的特点，用于热疗触发的局部药物递送。热响应性磁性碳酸氢铵脂质体的粒径和zeta电位分别约为210nm和-14mV。MagABC脂质体对磁性纳米颗粒（平均晶粒尺寸为12nm）和阿霉素（DOX）的包封率分别为15%和82%。使用透射电镜（TEM）观察MagABC脂质体的形态。MagABC脂质体显示出理想的热响应释放。与非磁性碳酸氢铵（ABC）脂质体相比，当通过永久磁场物理靶向培养的肿瘤细胞时，MagABC脂质体在细胞内的DOX积累显著增加。这导致在肿瘤细胞中，与负载DOX的ABC脂质体相比，负载DOX的MagABC脂质体的细胞毒性平行增加。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号