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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Biofilm-encapsulated nano drug delivery system for the treatment of colon cancer
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Biofilm-encapsulated nano drug delivery system for the treatment of colon cancer

机译：生物膜包封的纳米药物递送系统，用于治疗结肠癌

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Aim In this study, 5-fluorouracil (5-FU) is delivered to target colon without the interference of mononuclear phagocyte system (MPS). Methods Outer membrane vesicles (OMVs) were used as the biological shield to disguise mesoporous silica (MSN) and 5-FU. OMVs-MSN-5-FU were prepared by high pressure co-extrusion, and characterised on the basis of size, drug loading, transmission electron microscope, infra-red spectroscopy, differential scanning calorimetry, thermal gravity analysis, %in vitrorelease, MTT assay, cell uptake andin vivoimaging. Results OMVs-MSN-5-FU with -18.22 +/- 0.17 mV zeta potential and 90.4 +/- 9.1 nm size were used for oral treatment of colon cancer. Drug loading of the drug was 50.22%+/- 0.17 (w/w). The cumulative release of OMVs-MSN-5-FU reached 75.07%+/- 0.94 in tumour microenvironment. The percentage of cell viability of OMVs-MSN-5-FU was 33.75%+/- 2.73.In vivoexperiments results confirmed that OMVs-MSN-5-FU could be taken up by colon cancer cells. Conclusions The study provided a promising nano platform for the targeting treatment of colon cancer.
机译：目的在本研究中，5-氟尿嘧啶（5-FU）在不受单核吞噬细胞系统（MPS）干扰的情况下被输送到靶结肠。方法采用外膜囊泡（OMV）作为生物屏障，伪装介孔二氧化硅（MSN）和5-FU。采用高压共挤出法制备OMVs-MSN-5-FU，并根据大小、载药量、透射电子显微镜、红外光谱、差示扫描量热法、热重分析、%体外释放酶、MTT试验、细胞摄取和活体成像对其进行了表征。结果口服OMVs-MSN-5-FU，zeta电位-18.22+/-0.17mV，粒径90.4+/-9.1nm，用于结肠癌的治疗。载药量为50.22%+/-0.17（w/w）。OMVs-MSN-5-FU在肿瘤微环境中的累积释放量达到75.07%+/-0.94。OMVs-MSN-5-FU的细胞存活率为33.75%+/-2.73。活体实验结果证实OMVs-MSN-5-FU可被结肠癌细胞吸收。结论该研究为结肠癌的靶向治疗提供了一个有前景的纳米平台。

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