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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Optimisation of ethosomal nanogel for topical nano-CUR and sulphoraphane delivery in effective skin cancer therapy
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Optimisation of ethosomal nanogel for topical nano-CUR and sulphoraphane delivery in effective skin cancer therapy

机译：有效皮肤癌疗法中局部纳米Cur和亚膦酸乙酯的术语优化

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Aim: The optimisation and evaluation of ethosomal nanogel (NGs) for topical delivery in skin cancer. Methods: The formulations were optimised by employing 3-factor, 3-level Box Behnken design for responses of vesicle size, and fluxes. They characterised in vitro and evaluated for drug release, permeation and retention, skin penetration of ethosome, electron microscopy, texture analysis, and in vitro cytotoxicity. Results: The optimised formulation exhibited z-average 125.67 +/- 10.43 nm, apparent zeta potential -17.1 +/- 2.61 mV, average flux of drug loaded ethosome were 54.72 +/- 5.45 and 59.83 +/- 6.09 mu g/cm(2)/h. Further, Rhodamine B loaded ethosome penetrated deeper up to 183.82 mu m. The NGs texture analysis showed index of viscosity 225.45 g.s, firmness 209.34 g, cohesiveness -189.48 g, and consistency 59.45 g.s. The optimised ethosome NGs exhibited significant anti-cancer effect in B16-F10 murine tumour cell line (p < 0.05). Conclusion: Ethosomal NGs could be promising for skin cancer treatment.
机译：目的：优化和评估用于皮肤癌局部给药的醇质体纳米凝胶（NGs）。方法：采用三因素三水平Box-Behnken设计对囊泡大小和流量进行优化。他们在体外表征并评估药物释放、渗透和保留、醇质体的皮肤渗透、电子显微镜、质地分析和体外细胞毒性。结果：优化配方的z-平均值为125.67+/-10.43 nm，表观zeta电位为-17.1+/-2.61 mV，载药醇质体的平均通量为54.72+/-5.45和59.83+/-6.09μg/cm（2）/h。此外，罗丹明B载药醇质体的渗透深度达到183.82μm。NGs纹理分析显示粘度指数为225.45 g.s，硬度为209.34 g，内聚性为-189.48 g，一致性为59.45 g.s.优化的乙氧体NGs在B16-F10小鼠肿瘤细胞系中显示出显著的抗癌作用（p<0.05）。结论：醇质体NGs有望用于皮肤癌的治疗。

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