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首页> 外文期刊>Journal of Neuroscience Methods >Model-based geometrical optimisation and in vivo validation of a spatially selective multielectrode cuff array for vagus nerve neuromodulation
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Model-based geometrical optimisation and in vivo validation of a spatially selective multielectrode cuff array for vagus nerve neuromodulation

机译：基于模型的几何优化和迷走神经神经调节的空间选择性多电极袖带阵的体内验证

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Background: Neuromodulation by electrical stimulation of the human cervical vagus nerve may be limited by adverse side effects due to stimulation of off-target organs. It may be possible to overcome this by spatially selective stimulation of peripheral nerves. Preliminary studies have shown this is possible using a cylindrical multielectrode human-sized nerve cuff in vagus nerve selective neuromodulation. New method: The model-based optimisation method for multi-electrode geometric design is presented. The method was applied for vagus nerve cuff array and suggested two rings of 14 electrodes, 3 mm apart, with 0.4 mm electrode width and separation and length 0.5-3 mm, with stimulation through a pair in the same radial position on the two rings. The electrodes were fabricated using PDMS-embedded stainless steel foil and PEDOT: pTS coating. Results: In the cervical vagus nerve in anaesthetised sheep, it was possible to selectively reduce the respiratory breath rate (RBR) by 85 ? 5% without affecting heart rate, or selectively reduce heart rate (HR) by 20 ? 7% without affecting respiratory rate. The cardiac-and pulmonary-specific sites on the nerve cross-sectional perimeter were localised with a radial separation of 105 ? 5 degrees (P < 0.01, N = 24 in 12 sheep). Conclusions: Results suggest organotopic or function-specific organisation of neural fibres in the cervical vagus nerve. The optimised electrode array demonstrated selective electrical neuromodulation without adverse side effects. It may be possible to translate this to improved treatment by electrical autonomic neuromodulation for currently intractable conditions.
机译：背景：电刺激人颈迷走神经的神经调节可能会因刺激靶器官而产生不良副作用而受到限制。通过对周围神经进行空间选择性刺激，可以克服这一问题。初步研究表明，在迷走神经选择性神经调节中使用圆柱形多电极人体大小的神经套是可能的。新方法：提出了基于模型的多电极几何优化设计方法。该方法应用于迷走神经袖套阵列，建议使用两个环，14个电极，间隔3mm，电极宽度0.4mm，间隔0.5-3mm，通过两个环上相同径向位置的一对电极进行刺激。电极采用PDMS嵌入不锈钢箔和PEDOT:pTS涂层制成。结果：在麻醉绵羊的颈迷走神经中，有可能选择性地将呼吸频率（RBR）降低85？5%而不影响心率，或选择性地将心率（HR）降低20？7%，不影响呼吸频率。神经横截面周长上的心脏和肺特异性部位的径向间隔为105°？5度（P<0.01，12只绵羊的N=24）。结论：结果提示颈迷走神经中的神经纤维具有器官性或功能特异性组织。优化后的电极阵列显示出选择性神经电调节，没有不良副作用。这可能会转化为通过电自主神经调节改善目前难治性疾病的治疗。

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