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首页> 外文期刊>Journal of opioid management >Clinical analgesia correlates with decline in temporal summation in response to remifentanil infusion in patients with chronic neuropathic (radicular) pain
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Clinical analgesia correlates with decline in temporal summation in response to remifentanil infusion in patients with chronic neuropathic (radicular) pain

机译:临床镇痛与慢性神经治疗患者患者的Remifentanil输注的时间总和下降相关

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摘要

Background: Animal studies have shown that in addition to their antinociceptive effects, opioids have attenuated the electrophysiological "wind-up"phenomenon. Although effects of opioids on clinical pain and on temporal summation (TS), the human correlatives of this phenomenon, have been tested repeatedly, correlations between these two parameters have not been reported so far. Objectives: To search for possible correlations between the effects of remifentanil on clinical pain intensity and on the magnitude of TS in patients with chronic pain. Design: A single-blinded prospective study. Setting: A tertiary care pain clinic. Patients: Thirty-one patients (24 men) with chronic lumbar (radicular) neuro-pathic pain. Intervention: Intervenous administration of saline followed by remifentanil infusions. Main Outcome Measures: Clinical pain intensity and thermal TS measured at baseline, during infusion of each drug and 20 minutes after termination of remifentnail infusion.
机译:背景:动物研究表明,阿片类药物除了具有抗伤害作用外,还可以减弱电生理“上卷”现象。虽然阿片类药物对临床疼痛和时间总和(TS)的影响——这一现象的人类相关性——已被反复测试,但迄今为止,这两个参数之间的相关性尚未报道。目的:探讨瑞芬太尼对慢性疼痛患者临床疼痛强度和TS强度的影响之间可能存在的相关性。设计:单盲前瞻性研究。环境:一家三级护理疼痛诊所。患者:31名患者(24名男性)患有慢性腰(根)神经性疼痛。干预:干预性给药生理盐水,然后输注瑞芬太尼。主要观察指标:基线检查时、输注每种药物期间和瑞芬太尼输注终止后20分钟测量的临床疼痛强度和热T。

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