Characteristics and causes of death in children with neonatal abstinence syndrome

Uebel Hannah; Wright Ian M.; Burns Lucinda; Hilder Lisa; Bajuk Barbara; Breen Courtney; Abdel-Latif Mohamed E.; Falconer Janet; Clews Sarah; Ward Meredith; Eastwood John; Oei Ju Lee

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Characteristics and causes of death in children with neonatal abstinence syndrome

机译：新生儿禁忌综合征儿童死亡的特征与原因

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Aim To determine characteristics of death in children with neonatal abstinence syndrome (NAS). Methods A population-based linkage study of children from birth to 13 years of age in New South Wales (NSW), Australia, born 1 July 2000 to 31 December 2011. Infants with an International Statistical Classification of Diseases and Related Problems, Australian modification coding of NAS (P96.1,n= 3842) were compared to infants (n= 1 018 421) without NAS by birth, hospitalisation and death records linkage. Results Forty-five (1.2%) children with NAS died, compared to 3665 (0.4%) other children. Most deaths (n= 30, 66%) in NAS children occurred between 1 month and 1 year. Risk of death was independently increased in full-term children (hazard ratio 2.34, 95% confidence interval 1.63-3.35;P < 0.001) from lower socio-economic groups (1.23, 1.12-1.35;P < 0.001), most commonly from ill-defined or external causes, including assault and accidents (P < 0.001). Conclusions Children with NAS, especially those of term gestation and from lower socio-economic groups, are more likely to die, especially from external causes.

机译：目的确定新生儿禁欲综合征（NAS）患儿的死亡特征。方法对2000年7月1日至2011年12月31日出生于澳大利亚新南威尔士州（NSW）的出生至13岁儿童进行基于人群的连锁研究。根据出生、住院和死亡记录，将患有国际疾病和相关问题统计分类、澳大利亚NAS修改编码（P96.1，n=3842）的婴儿与无NAS的婴儿（n=1018 421）进行比较。结果NAS患儿死亡45例（1.2%），其他患儿死亡3665例（0.4%）。NAS儿童的大多数死亡（n=30，66%）发生在1个月到1岁之间。来自较低社会经济群体（1.23,1.12-1.35；P<0.001）的足月儿童的死亡风险独立增加（危险比2.34，95%置信区间1.63-3.35；P<0.001），最常见的原因是定义不清或外部原因，包括袭击和事故（P<0.001）。结论NAS患儿，尤其是足月妊娠和社会经济地位较低的人群，更容易死亡，尤其是死于外部原因。

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来源
《Journal of paediatrics and child health》 |2020年第12期|共8页
作者
Uebel Hannah; Wright Ian M.; Burns Lucinda; Hilder Lisa; Bajuk Barbara; Breen Courtney; Abdel-Latif Mohamed E.; Falconer Janet; Clews Sarah; Ward Meredith; Eastwood John; Oei Ju Lee;
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作者单位

Univ New South Wales Sch Womens &

Childrens Heath Sydney NSW Australia;

James Cook Univ Coll Med &

Dent Cairns Qld Australia;

Univ New South Wales Natl Drug &

Alcohol Res Ctr Sydney NSW Australia;

Univ New South Wales Natl Drug &

Alcohol Res Ctr Sydney NSW Australia;

Sydney Childrens Hosp Perinatal Serv Network Sydney NSW Australia;

Univ New South Wales Natl Drug &

Alcohol Res Ctr Sydney NSW Australia;

Canberra Hosp Dept Neonatol Canberra ACT Australia;

Royal Hosp Women Langton Ctr Sydney NSW Australia;

Royal Hosp Women Langton Ctr Sydney NSW Australia;

Univ New South Wales Sch Womens &

Childrens Heath Sydney NSW Australia;

Univ New South Wales Sch Womens &

Childrens Heath Sydney NSW Australia;

Univ New South Wales Sch Womens &

Childrens Heath Sydney NSW Australia;

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原文格式 PDF
正文语种 eng
中图分类儿科学;
关键词
childhood mortality; linkage; neonatal abstinence syndrome;

机译：儿童死亡率;联动;新生儿禁欲综合征;

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Characteristics and causes of death in children with neonatal abstinence syndrome

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