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首页> 外文期刊>Journal of orthopaedic research >Part 1. Review and meta-analysis of studies on modulation of longitudinal bone growth and growth plate activity: A macro-scale perspective
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Part 1. Review and meta-analysis of studies on modulation of longitudinal bone growth and growth plate activity: A macro-scale perspective

机译：第1部分。综合性骨生长和生长板活性调节研究的审查和荟萃分析：宏观展示

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Growth modulation is an emerging method for treatment of angular skeletal deformities such as adolescent idiopathic scoliosis (AIS). The Hueter-Volkmann law, by which growth is stimulated in tension and inhibited in compression, is widely understood, and applied in current growth-modulating interventions such as anterior vertebral body tethering (AVBT) for AIS. However, without quantification of the growth rate effects of tension or compression, the possibility of under- or over- correction exists. A definitive mechanical growth modulation relationship relating to treatment of such skeletal deformities is yet to exist, and the mechanisms by which growth rate is regulated and altered are not fully defined. Review of current literature demonstrates that longitudinal (i.e., lengthwise) growth rate in multiple animal models depend on load magnitude, anatomical location, and species. Additionally, alterations in growth plate morphology and viability vary by loading parameters such as magnitude, frequency, and whether the load was applied persistently or intermittently. The aggregate findings of the reviewed studies will assist in work towards increasingly precise and clinically successful growth modulation methods. Part 1 of this review focuses on the effects of mechanical loading, species, age, and anatomical location on the macro-scale alterations in longitudinal bone growth, as well as factors that affect growth plate material properties. Part 2 considers the effects on micro-scale alterations in growth plate morphology such as zone heights and proportions, chondrocyte viability, and related gene and protein expression.
机译：生长调节是治疗青少年特发性脊柱侧凸（AIS）等角形骨骼畸形的一种新兴方法。Hueter-Volkmann定律被广泛理解，在张力下刺激生长，在压力下抑制生长，并应用于当前的生长调节干预措施，如AIS的前椎体栓系（AVBT）。然而，如果没有对拉伸或压缩的增长率效应进行量化，则可能存在校正不足或过度的情况。与此类骨骼畸形的治疗相关的明确的机械生长调节关系尚不存在，并且生长速率的调节和改变机制尚未完全确定。对现有文献的回顾表明，多种动物模型的纵向（即纵向）生长率取决于负荷大小、解剖位置和物种。此外，生长板形态和生存能力的改变因负荷参数而不同，如大小、频率，以及负荷是持续施加还是间歇施加。经过审查的研究的总体结果将有助于实现越来越精确和临床上成功的生长调节方法。本综述的第1部分重点介绍了机械负荷、物种、年龄和解剖位置对纵向骨生长宏观变化的影响，以及影响生长板材料性能的因素。第2部分考虑了生长板形态的微尺度改变的影响，如区域高度和比例、软骨细胞活力以及相关基因和蛋白质表达。

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