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首页> 外文期刊>Journal of orthopaedic research >Unicompartmental bipolar osteochondral and meniscal allograft transplantation is effective for treatment of medial compartment gonarthrosis in a canine model
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Unicompartmental bipolar osteochondral and meniscal allograft transplantation is effective for treatment of medial compartment gonarthrosis in a canine model

机译：Unicompartmallal Bipolar骨质色神经和半月板同种异体移植是有效的，用于治疗犬模型中的内侧室吞咽术

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Osteochondral allograft (OCA) transplantation can restore large articular defects in the knee. Bipolar OCA transplantations for partial and whole joint resurfacing often have less favorable results than single-surface transplants. This study was designed to use a large animal model to test the hypothesis that unicompartmental bipolar osteochondral and meniscal allograft transplantation (BioJoint) would be as or more effective for treatment of medial compartment osteoarthritis (OA) compared to standard-of-care nonoperative treatment. OA was induced in one knee of each research hound (n = 8) using a meniscal release model and pretreatment assessments were performed. After 3 months, dogs were randomly assigned to either the control group (n = 4, no surgical intervention, daily nonsteroidal antiinflammatory drugs [NSAIDs]) or the BioJoint group (n = 4). Clinical, radiographic, and arthroscopic assessments were performed longitudinally and histopathology was evaluated at the 6-month endpoint. At study endpoint, functional, pain, and total pressure index measures, as well as radiographic and arthroscopic grading of graft appearance and joint health, demonstrated superior outcomes for BioJoints compared to NSAID controls. Furthermore, histologic assessments showed that osteochondral and meniscal transplants maintain integrity and integrated into host tissues. Clinical significance: The results support the safety and efficacy of unicompartmental bipolar osteochondral and meniscal allograft transplantation in a preclinical model with highly functional outcomes without early OA progression.
机译：同种异体骨软骨移植（OCA）可修复膝关节大面积缺损。双极OCA移植用于局部和整体关节表面重建的效果往往不如单面移植。本研究旨在使用大型动物模型，验证单室双极骨软骨和半月板同种异体移植（BioJoint）治疗内侧间隔骨关节炎（OA）与标准护理非手术治疗效果相同或更有效的假设。使用半月板释放模型在每只研究犬（n=8）的一个膝盖上诱发OA，并进行预处理评估。3个月后，将狗随机分为对照组（n=4，无手术干预，每日服用非甾体抗炎药[NSAIDs]）或生物关节组（n=4）。临床、放射学和关节镜评估在6个月结束时进行纵向和组织病理学评估。在研究终点，功能、疼痛和总压指数测量，以及移植外观和关节健康的放射学和关节镜分级显示，与NSAID对照组相比，生物关节的疗效更好。此外，组织学评估显示，骨软骨和半月板移植保持完整性，并整合到宿主组织中。临床意义：研究结果支持单室双极骨软骨和半月板同种异体移植在临床前模型中的安全性和有效性，该模型具有高度的功能性结果，无早期OA进展。

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