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首页> 外文期刊>Journal of oral rehabilitation >Correlates and genetics of self-reported sleep and awake bruxism in a nationwide twin cohort
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Correlates and genetics of self-reported sleep and awake bruxism in a nationwide twin cohort

机译：在全国双胞胎队列中的自我报告的睡眠和清醒胸膜的关联和遗传

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Background Sleep bruxism (SB) and awake bruxism (AB) have been considered different entities, although co-occurrence between them has been shown. While genetic factors have a marked influence on phenotypic variance in liability to SB, this remains unclear for AB. Aim To examine the degree of co-occurrence of SB and AB, and whether they have common correlates and also twin similarity of SB and AB bruxism traits by zygosity and sex. Methods A questionnaire was mailed to all twins born 1945-1957 in Finland in 2012 (n = 11 766). Age and sex adjusted logistic regression models were used. Twin similarity was assessed using polychoric correlations, and crosstwin-crosstrait correlations were computed. Results The response rate was 72% (n = 8410). Any SB was reported by 14.8% and >= 3 nights weekly by 5.0%. Percentages for any AB were 18.4% and 6.3%, respectively. There was substantial co-occurrence (29.5%) between SB and AB, and several shared correlates were found. For SB, the polychoric intra-class correlation was 0.366 in monozygotic (MZ) and 0.200 in dizygotic (DZ) pairs, without gender difference. A twofold crosstwin-crosstrait correlation was observed in MZ twins compared to DZ twins. Conclusions The risk factor profiles of SB and AB were largely but not entirely similar. The higher correlation in MZ than in DZ pairs suggests the influence of genetic factors on both SB and AB. The higher crosstwin-crosstrait correlation in MZ than in DZ pairs suggests some degree of genetic influences shared by SB and AB.
机译：背景睡眠磨牙症（SB）和清醒磨牙症（AB）被认为是不同的实体，尽管已经证明它们之间是共存的。虽然遗传因素对SB易感性的表型变异有显著影响，但对于AB来说，这一点尚不清楚。目的是研究SB和AB共现的程度，以及它们是否具有共同的相关性，以及SB和AB磨牙症性状在合子性和性别方面是否具有孪生相似性。方法对2012年出生于芬兰1945-1957年的所有双胞胎（n=11766）进行问卷调查。采用年龄和性别调整后的logistic回归模型。使用多基因相关评估双胞胎相似性，并计算交叉性状相关。结果有效率为72%（n=8410）。任何SB的报告率为14.8%，每周>=3晚的报告率为5.0%。任何抗体的百分比分别为18.4%和6.3%。SB和AB之间存在大量共现（29.5%），并且发现了几个共同的相关性。对于SB，单合子（MZ）对的多基因类内相关为0.366，双合子（DZ）对的多基因类内相关为0.200，没有性别差异。在MZ双生子和DZ双生子中观察到双重交叉性状相关。结论SB和AB的危险因素在很大程度上相似，但并不完全相似。MZ比DZ对的相关性更高，表明遗传因素对SB和AB都有影响。MZ比DZ对的交叉孪生性状相关性更高，表明SB和AB共享一定程度的遗传影响。

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