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Prenatal screening diagnosis and management in the era of coronavirus: the Sardinian experience

机译:冠状病毒时代的产前筛查诊断和管理:撒丁岛经验

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摘要

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a new coronavirus, was first identified in December 2019 in Wuhan, China and spread rapidly, affecting many other countries. The disease is now referred to as coronavirus disease 2019 (COVID-19).The Italian government declared a state of emergency on 31st January 2020 and on 11th March World Health Organization (WHO) officially declared the COVID-19 outbreak a global pandemic. Although the COVID-19 incidence remained considerably lower in Sardinia than in the North Italy regions, which were the most affected, the field of prenatal screening and diagnosis was modified because of the emerging pandemic. Data on COVID-19 during pregnancy are so far limited. Since the beginning of the emergency, our Ob/Gyn Department at Microcitemico Hospital, Cagliari offered to pregnant patients all procedures considered essential by the Italian Ministry of Health. To evaluate the influence of the COVID-19 pandemic on the activities of our center, we compared the number of procedures performed from 10th March to 18th May 2020 with those of 2019. Despite the continuous local birth rate decline, during the 10-week pandemic period, we registered a 20% increment of 1st trimester combined screening and a slight rise of the number of invasive prenatal procedures with a further increase in chorionic villi sampling compared to amniocentesis. Noninvasive prenatal testing remained unvariated. The request for multifetal pregnancy reduction as a part of the growing tendency of voluntary termination of pregnancy in Sardinia increased. The COVID-19 pandemic provides many scientific opportunities for clinical research and study of psychological and ethical issues in pregnant women.
机译:严重急性呼吸综合征冠状病毒2(SARS-CoV-2)是一种新型冠状病毒,于2019年12月在中国武汉首次发现,并迅速传播,影响到许多其他国家。这种疾病现在被称为2019年冠状病毒病(COVID-19)。意大利政府急诊科2019冠状病毒疾病爆发,2020年1月31日和3月11日宣布世界卫生组织(WHO)正式宣布全球流感大流行。虽然撒丁岛2019冠状病毒疾病的发病率仍然比意大利北部地区低,但由于新出现的流行,产前筛查和诊断的领域被修改。怀孕期间2019冠状病毒疾病的数据是有限的。自紧急情况开始以来,我们在卡利亚里Microcitemico医院的妇产科为怀孕患者提供了意大利卫生部认为必要的所有程序。为了评估2019冠状病毒疾病对我们中心活动的影响,我们比较了3月10日至2020年5月18日的2019个疗程。尽管本地出生率持续下降,但在10周的大流行期间,我们记录了孕早期联合筛查增加了20%,侵入性产前检查的数量略有增加,与羊膜穿刺术相比,绒毛取样进一步增加。无创性产前检查仍保持不变。作为撒丁岛自愿终止妊娠日益增长趋势的一部分,减少多胎妊娠的要求有所增加。2019冠状病毒疾病的流行为临床研究和研究孕妇心理和伦理问题提供了许多科学机会。

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