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首页> 外文期刊>Journal of public health dentistry >Endodontic therapy and incident cardiovascular disease: The Atherosclerosis Risk in Communities (ARIC) study
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Endodontic therapy and incident cardiovascular disease: The Atherosclerosis Risk in Communities (ARIC) study

机译：牙髓治疗和事件心血管疾病：社区（ARIC）研究中的动脉粥样硬化风险

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Abstract Objectives Previous studies on a potential association between endodontic infection (EI) and cardiovascular disease (CVD) produced mixed results. Endodontic treatment (ET) may also be linked to cardiovascular risk, as a marker for prior chronic dental infection and subclinical EI in other teeth. We tested the hypothesis that ET is associated with elevated risk of coronary heart disease (CHD), ischemic stroke (IS), heart failure (HF), or venous thromboembolism (VTE). Methods ARIC participants who completed the dental ancillary study exam 4 (1996–1998; n = 6,638) were included in the analyses. Participants were followed through 2013 for CHD, stroke, and HF and 2011 for VTE. Cox‐proportional hazards regression models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for CHD, IS, HF, and VTE across ET classifications adjusting for age, sex, race/center, education, income, smoking, alcohol consumption, BMI, statin use, family history of CHD, physical activity, diet quality, insurance status, last dental visit, dental visit frequency, having a current dentist, and tooth loss due to gum disease. Results Among participants, 21.0% reported a single ET, while 28.5% reported multiple ETs. Over a median of 15.8?years of follow‐up, there were 506 incident CHD events, 311 IS events, 739 HF events, and 219 VTE events. There were no significant associations between self‐reported history of ET and any of our outcomes (HR (95%CI): CHD = 1.16 (0.87,1.44), IS = 0.77 (0.55,1.09), HF = 1.00 (0.81,1.24), VTE = 0.98 (0.67,1.43)) after adjustment. Conclusions Our results do not support an independent association between ET and development of CHD, IS, HF, or VTE.
机译：摘要目的以往关于牙髓感染（EI）与心血管疾病（CVD）之间潜在关联的研究结果不一。牙髓治疗（ET）也可能与心血管风险有关，作为先前慢性牙齿感染和其他牙齿亚临床EI的标志。我们验证了ET与冠心病（CHD）、缺血性中风（is）、心力衰竭（HF）或静脉血栓栓塞（VTE）风险升高相关的假设。方法完成牙科辅助研究考试4（1996-1998；n=6638）的ARIC参与者纳入分析。研究人员对参与者进行了为期2013年的CHD、中风和HF随访，并于2011年进行了VTE随访。Cox比例风险回归模型用于评估ET分类中CHD、IS、HF和VTE的风险比（HR）和95%置信区间（CI），并根据年龄、性别、种族/中心、教育程度、收入、吸烟、饮酒、BMI、他汀类药物使用、CHD家族史、体力活动、饮食质量、保险状况、最后一次牙科就诊、牙科就诊频率、，现在有牙医，牙齿因牙龈疾病脱落。结果在参与者中，21.0%的人报告了单一ET，而28.5%的人报告了多个ET。超过中位数15.8？经过多年的随访，共有506例CHD事件、311例IS事件、739例HF事件和219例VTE事件。自我报告的ET病史与我们调整后的任何结果（HR（95%CI）：CHD=1.16（0.87,1.44），IS=0.77（0.55,1.09），HF=1.00（0.81,1.24），VTE=0.98（0.67,1.43））之间没有显著相关性。结论我们的结果不支持ET与CHD、IS、HF或VTE之间的独立相关性。

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