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首页> 外文期刊>Journal of Reproductive Immunology >Decreased circulating levels of plasmacytoid dendritic cells in women with early-onset preeclampsia
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Decreased circulating levels of plasmacytoid dendritic cells in women with early-onset preeclampsia

机译：患有早期发作前先兆子痫的妇女中血浆骨质树突细胞的循环水平降低

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The role of plasmacytoid dendritic cells (pDCs), and myeloid dendritic cells (mDCs) in women with preeclampsia has not been elucidated. We compared the frequency of peripheral pDCs, mDCs, NK cells, and T helper 17 (Th17) cells among non-pregnant/pregnant women, and women with early-/late-onset preeclampsia. We examined pDCs and mDCs using Anti-Human Lineage Cocktail 3 (CD3, CD14, CD19, and CD20), HLA-DR, CD11c, and CD123. We detected NK cells using Lineage cocktail, CD8, CD16, and CD56. We determined Th17 cells using CD3, CD4, CD8, CXCR3, and CCR6. We recruited 13 non-pregnant women, 50 normal pregnant women, 13 women with early-onset preeclampsia (onset at < 34 gestational weeks), and 10 women with late-onset preeclampsia. The fraction of pDCs in women with early-onset preeclampsia was significantly lower than in non pregnant women and normal pregnant women at 19-29 gestational weeks (4.1 % vs. 41.2 % and 19.0 %, respectively [p = 0.0005, and p = 0.025]), however, the fraction of pDCs in late-onset preeclampsia was not significantly different from normal pregnant women at 37 gestational weeks (11.1 % vs. 29.1 %, respectively [p = 0.149]), although it was significantly lower than in non-pregnant women (11.1 % vs. 41.2 %, respectively [p = 0.044]). The fraction of Th17 cells in women with early-onset preeclampsia was significantly higher than in normal pregnant women at 19-29 gestational weeks (p = 0.022). In conclusion, the level of circulating pDCs was lower in early-onset preeclampsia than in non-pregnant and pregnant women, suggesting the role of pDCs in the pathogenesis of early-onset preeclampsia.
机译：浆细胞样树突状细胞（PDC）和髓样树突状细胞（MDC）在先兆子痫妇女中的作用尚未阐明。我们比较了非孕妇/孕妇和早发/晚发先兆子痫患者外周血PDC、MDC、NK细胞和T辅助细胞17（Th17）的频率。我们使用抗人类谱系鸡尾酒3（CD3、CD14、CD19和CD20）、HLA-DR、CD11c和CD123检测PDC和MDC。我们使用谱系鸡尾酒、CD8、CD16和CD56检测NK细胞。我们使用CD3、CD4、CD8、CXCR3和CCR6检测Th17细胞。我们招募了13名非孕妇、50名正常孕妇、13名早发性先兆子痫患者（发病时间<34孕周）和10名晚发性先兆子痫患者。然而，在19-29孕周，早发性子痫前期妇女的PDC分数显著低于非孕妇和正常孕妇（分别为4.1%和41.2%及19.0%[p=0.0005和p=0.025]），晚发性先兆子痫患者的PDC分数在37孕周时与正常孕妇无显著差异（分别为11.1%和29.1%[p=0.149]），但明显低于非孕妇（分别为11.1%和41.2%[p=0.044]）。在19-29孕周，早发性子痫前期妇女的Th17细胞比例显著高于正常孕妇（p=0.022）。综上所述，早发性子痫前期患者循环PDC水平低于非孕妇和孕妇，提示PDC在早发性子痫前期发病机制中的作用。

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