...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Reproductive Immunology >Autophagy regulation in preeclampsia: Pros and cons
【24h】

Autophagy regulation in preeclampsia: Pros and cons

机译：预贷方的自噬条例：优点和缺点

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Highlights ? Autophagy is an evolutionarily conserved process in eukaryotes to maintain cellular homeostasis against stress. ? Autophagy activation is observed in EVTs during early pregnant period in vivo , suggesting that EVTs use autophagy for adjusting to hypoxic and low-nutrient conditions. On the other hand, soluble endoglin inhibits autophagy in vitro , resulting in suppression of EVT functions. ? There are some opposing reports in which autophagy activation was more frequently observed in preeclamptic or FGR placentas than in normal pregnancy. ? It is still unknown how autophagy contributes to pathophysiology of preeclampsia. ? This review introduces the role of autophagy for maintaining pregnancy and its correlation with preeclampsia. Abstract Autophagy is an evolutionarily conserved process in eukaryotes to maintain cellular homeostasis against stress. This process has two main functions: producing energy and quality control of intracellular proteins. During early pregnancy, extravillous trophoblasts (EVTs) invade the uterine myometrium and migrate along the lumina of spiral arterioles under hypoxic and low-nutrient conditions. Autophagy activation is observed in EVTs under these conditions, suggesting that EVTs use autophagy for adjusting to such harsh conditions. On the other hand, soluble endoglin, which is increased in sera in preeclamptic cases, inhibits autophagy in vitro , resulting in suppression of EVT functions, invasion and vascular remodeling. In addition, p62/SQSTM1, a substrate degraded by autophagy, accumulates in EVTs in preeclamptic placental biopsy samples, exhibiting impaired autophagy in vivo . There are, however, some opposing reports in which autophagy activation, an increase of autophagy vacuoles or LC3 dots, was more frequently observed in preeclamptic or FGR placentas than in normal pregnancy. Thus, changes in autophagy status are seen in preeclamptic placentas, but the mechanism by which autophagy modulates biological changes in the placentas is still unknown. Recently, there is increasing evidence that autophagy is involved in maintaining pregnancy. This review introduces the role of autophagy for maintaining pregnancy and its correlation with preeclampsia.
机译：亮点？自噬在真核生物中是一个进化上保守的过程，可以维持细胞内稳态以抵抗压力？在体内妊娠早期，EVT中观察到自噬激活，这表明EVT利用自噬调节缺氧和低营养条件。另一方面，可溶性内皮素在体外抑制自噬，从而抑制EVT功能？有一些相反的报道称，与正常妊娠相比，在先兆子痫或FGR胎盘中更频繁地观察到自噬激活？自噬如何影响先兆子痫的病理生理尚不清楚？本文综述了自噬在维持妊娠中的作用及其与子痫前期的关系。摘要自噬在真核生物中是一个进化上保守的过程，可以维持细胞内稳态以抵抗应激。这个过程有两个主要功能：产生能量和细胞内蛋白质的质量控制。在妊娠早期，绒毛外滋养层细胞（EVT）侵入子宫肌层，并在缺氧和低营养条件下沿螺旋小动脉腔迁移。在这些条件下，EVT中观察到自噬激活，这表明EVT利用自噬来适应这种严酷的条件。另一方面，先兆子痫患者血清中增加的可溶性内皮素在体外抑制自噬，从而抑制EVT功能、侵袭和血管重塑。此外，p62/SQSTM1是一种通过自噬降解的底物，在先兆子痫胎盘活检样本的EVT中积累，显示体内自噬受损。然而，也有一些相反的报道，与正常妊娠相比，在子痫前期或FGR胎盘中更频繁地观察到自噬激活，即自噬空泡或LC3点的增加。因此，在子痫前期胎盘中可以看到自噬状态的变化，但自噬调节胎盘生物变化的机制仍不清楚。最近，越来越多的证据表明自噬参与维持妊娠。本文综述了自噬在维持妊娠中的作用及其与子痫前期的关系。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号