...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Reproductive Immunology >A randomized exploratory trial to assess the effects of resveratrol on VEGF and TNF-alpha 2 expression in endometriosis women
【24h】

A randomized exploratory trial to assess the effects of resveratrol on VEGF and TNF-alpha 2 expression in endometriosis women

机译：一种随机探索性试验，以评估白藜芦醇对子宫内膜异位症女性VEGF和TNF-α的表达的影响

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Resveratrol, a naturally synthesized polyphenolic compound found in some fruits, has anti neoplastic, anti-inflammatory, anti-oxidative, and anti-angiogenic properties. Angiogenesis is an important process in endometriosis which provides blood supply for implantation, proliferation and survival of endometriotic lesions. In this study, we assessed the effects of resveratrol on vascular endothelial growth factor (VEGF) and tumor necrosis factor alpha (TNF-alpha) expression in the eutopic endometrium of infertile patients with endometriosis within the window of implantation as a randomized exploratory trial. Subjects, who confirmed their endometriosis (stage III-IV) by a pathologist after laparoscopic surgery, were recruited to the present trial. A total of 34 patients were randomly divided into treatment (n = 17) and control (n = 17) groups, beside the routine protocol for treatment of endometriosis, they received resveratrol and placebo (400 mg) for 12-14 weeks, respectively. Endometrial tissue was collected from both groups before and after the intervention in the mid-secretory phase. Gene and protein expression levels of VEGF and TNF-alpha in the eutopic endometrium were assessed by Real-Time PCR and Western blotting, respectively. VEGF and TNF-alpha gene and protein levels in the treatment group showed significant decrease following intervention. It seems resveratrol may improve the endometrium of endometriosis patients in window of implantation period by modifying the expression of VEGF and TNF-alpha but further investigations are needed to reveal the potential role of this compound.
机译：白藜芦醇是一种天然合成的多酚化合物，存在于一些水果中，具有抗肿瘤、抗炎、抗氧化和抗血管生成的特性。血管生成是子宫内膜异位症的一个重要过程，为子宫内膜异位症病变的植入、增殖和存活提供血液供应。在这项研究中，我们评估了白藜芦醇对植入窗口内子宫内膜异位症不孕症患者在位子宫内膜中血管内皮生长因子（VEGF）和肿瘤坏死因子-α（TNF-α）表达的影响，作为一项随机探索性试验。受试者在腹腔镜手术后由病理学家确认患有子宫内膜异位症（III-IV期），被纳入本试验。共有34名患者被随机分为治疗组（n=17）和对照组（n=17），除了治疗子宫内膜异位症的常规方案外，他们分别接受白藜芦醇和安慰剂（400 mg）治疗12-14周。在分泌中期干预前后收集两组的子宫内膜组织。分别通过实时PCR和Western印迹检测在位子宫内膜中VEGF和TNF-α的基因和蛋白质表达水平。干预后，治疗组的VEGF和TNF-α基因和蛋白质水平显著降低。白藜芦醇似乎可以通过改变VEGF和TNF-α的表达来改善植入期子宫内膜异位症患者的子宫内膜，但还需要进一步的研究来揭示这种化合物的潜在作用。

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号