...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Reproductive Immunology >Intrauterine administration of hCG-activated autologous human peripheral blood mononuclear cells (PBMC) promotes live birth rates in frozen/thawed embryo transfer cycles of patients with repeated implantation failure
【24h】

Intrauterine administration of hCG-activated autologous human peripheral blood mononuclear cells (PBMC) promotes live birth rates in frozen/thawed embryo transfer cycles of patients with repeated implantation failure

机译：HCG活化的自体的人外周血单核细胞（PBMC）宫内施用促进了患者反复植入失败的冷冻/解冻胚胎转移循环中的活产率

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Recurrent implantation failure refers to unsuccessful implantation after repeated transfers of morphologically good quality embryos into a normal uterus. Recently, accumulating evidence has suggested that local immune cells at the implantation site have actively contributed to embryo implantation. Our aim was to study the effects of intrauterine administration of hCG-activated autologous human PBMC on clinical pregnancy, implantation rates and live birth rate of patients who received frozen thawed embryo transfer. We observed patients with one to three failed transplantations cannot benefit from the administration, but the rate of clinical pregnancy (39.58% vs. 14.29%), live birth (33.33% vs. 9.58%) and implantation (22.00% vs. 4.88%) were significantly increased in patients with four or more failures, respectively. For patients with endometrial thickness more than 7mm and less than 8 mm on day of embryo transfer, the implantation rate (22.69% vs. 14.21%) and the live birth rate significantly higher in the PBMC-treated group; For patients who had RIF and received frozen/thawed early cleavage stage embryo transfer, the live birth delivery rate (29.63% vs. 13.33%) significant higher in PBMC-treated group. These findings indicate that intrauterine administration of hCG-activated autologous PBMC effectively improves the IVF outcomes for RIF patients, especially for the RIF patients with cleavage stage embryo transfer, patients with thin endometrial thickness also benefit from this approach. (C) 2016 Published by Elsevier Ireland Ltd.
机译：复发性植入失败是指将形态良好的胚胎反复移植到正常子宫后植入失败。最近，越来越多的证据表明，着床部位的局部免疫细胞对胚胎着床起到了积极的作用。我们的目的是研究宫内应用hCG激活的自体人外周血单个核细胞对接受冻融胚胎移植患者的临床妊娠率、植入率和活产率的影响。我们观察到，一到三次移植失败的患者不能从给药中获益，但四次或更多失败的患者的临床妊娠率（39.58%对14.29%）、活产率（33.33%对9.58%）和植入率（22.00%对4.88%）分别显著增加。对于胚胎移植当天子宫内膜厚度大于7mm且小于8mm的患者，PBMC治疗组的植入率（22.69%对14.21%）和活产率显著高于对照组；对于患有RIF并接受冷冻/解冻早期卵裂期胚胎移植的患者，PBMC治疗组的活产分娩率（29.63%对13.33%）显著高于对照组。这些发现表明，宫内应用hCG激活的自体PBMC可有效改善RIF患者的IVF结局，尤其是对于具有卵裂期胚胎移植的RIF患者，子宫内膜厚度较薄的患者也可受益于这种方法。（C） 2016年由爱思唯尔爱尔兰有限公司出版。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号