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首页> 外文期刊>Journal of Reproductive Immunology >Imbalance of uterine innate lymphoid cells is involved in the abnormal pregnancy induced by Toxoplasma gondii infection
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Imbalance of uterine innate lymphoid cells is involved in the abnormal pregnancy induced by Toxoplasma gondii infection

机译：子宫先天淋巴细胞的失衡涉及弓形虫感染诱导的异常妊娠

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摘要

Toxoplasma gondii (T. gondii) is a ubiquitous intracellular protozoan parasite that causes adverse pregnancy outcomes. Innate lymphoid cells (ILCs) are critical mediators of mucosal immunity, and have been reported to play an important role in uterine vascular adaptation for successful pregnancy. However, the specific role of ILCs in T. gondii-infection-induced adverse pregnancy outcomes remains elusive. In the present study, we found that T. gondii infection caused the imbalance of uterine ILC cells (uILCs). It was characterized by substantially lower expression of the transcription factor GATA-3 and ROR gamma t and higher expression of T-bet in uILCs. Consistent with the transcription factor changes, uILCs from T. gondii-infected mice produced much less IL-5 and IL-17 and substantially more IFN-gamma and TNF-alpha than did uILCs from uninfected mice. Notably, IL-12, IL-18, and their receptors were increased in the uterus of T. gondii-infected mice. In vitro experiments showed that IL-12 and IL-18 treatment reduced the percentages of uILC2 and uILC3 and increased the percentages of uILC1. Conclusion, our data suggest that alterations in uILC composition may disrupt the balance of immune microenvironment after T. gondii infection and contribute to the adverse pregnancy outcomes caused by T. gondii infection.
机译：弓形虫（T.gondii）是一种普遍存在的细胞内原生动物寄生虫，可导致不良妊娠结局。先天性淋巴细胞（ILC）是粘膜免疫的关键介质，据报道在成功妊娠的子宫血管适应中发挥重要作用。然而，ILC在弓形虫感染引起的不良妊娠结局中的具体作用仍不清楚。在本研究中，我们发现弓形虫感染导致子宫ILC细胞（uILCs）失衡。其特征是转录因子GATA-3和RORγt在uILCs中的表达显著降低，而t-bet在uILCs中的表达显著升高。与转录因子的变化一致，弓形虫感染小鼠的uILCs产生的IL-5和IL-17比未感染小鼠的uILCs少得多，而IFN-γ和TNF-α则显著增加。值得注意的是，感染弓形虫的小鼠子宫中的IL-12、IL-18及其受体增加。体外实验表明，IL-12和IL-18处理降低了uILC2和uILC3的百分比，增加了uILC1的百分比。结论：我们的数据表明，在弓形虫感染后，uILC成分的改变可能会破坏免疫微环境的平衡，并导致弓形虫感染导致的不良妊娠结局。

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  • 来源
    《Journal of Reproductive Immunology》 |2021年第1期|共12页
  • 作者

    Liu Siqi; Liu Qi; Xie Huiyuan; Li Minmin; Wang Fuyan; Shen Jijia; Liu Miao; Ren Cuiping; Hou Xin;

  • 作者单位

    Anhui Med Univ Sch Basic Med Sci Anhui Prov Lab Microbiol &

    Parasitol Hefei Peoples R China;

    Anhui Med Univ Sch Basic Med Sci Anhui Prov Lab Microbiol &

    Parasitol Hefei Peoples R China;

    Anhui Med Univ Sch Basic Med Sci Anhui Prov Lab Microbiol &

    Parasitol Hefei Peoples R China;

    Anhui Med Univ Sch Basic Med Sci Anhui Prov Lab Microbiol &

    Parasitol Hefei Peoples R China;

    Ningbo Univ Sch Med Ningbo Peoples R China;

    Anhui Med Univ Sch Basic Med Sci Anhui Prov Lab Microbiol &

    Parasitol Hefei Peoples R China;

    Anhui Med Univ Sch Basic Med Sci Anhui Prov Lab Microbiol &

    Parasitol Hefei Peoples R China;

    Anhui Med Univ Sch Basic Med Sci Anhui Prov Lab Microbiol &

    Parasitol Hefei Peoples R China;

    Anhui Med Univ Sch Basic Med Sci Anhui Prov Lab Microbiol &

    Parasitol Hefei Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 妇科学;
  • 关键词

    Toxoplasma gondii; Innate lymphoid cells; Imbalance; IL-12; Adverse pregnant outcome;

    机译：弓形虫;固有淋巴细胞;不平衡IL-12;不良妊娠结局;

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