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首页> 外文期刊>Journal of Parasitology >MICROBIOME DIFFERENCES BETWEEN HUMAN HEAD AND BODY LICE ECOTYPES REVEALED BY 16S RRNA GENE AMPLICON SEQUENCING
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MICROBIOME DIFFERENCES BETWEEN HUMAN HEAD AND BODY LICE ECOTYPES REVEALED BY 16S RRNA GENE AMPLICON SEQUENCING

机译：人头和身体之间的微生物组差异，患有16S rRNA基因扩增子测序的液体液相型

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摘要

Human head lice and body lice (Pediculus humanus) are neglected ectoparasites. Head lice continue to be prevalent in children worldwide, and insecticide resistance in these insects has complicated their treatment. Meanwhile, body lice, which are most common in the developing world, are resurging among marginalized populations in developed nations. Today, the microbiome is being increasingly recognized as a key mediator of insect physiology. However, the microbial communities that inhabit human lice have remained unknown beyond only a few species of bacteria. Knowledge of the microbiomes of head and body lice could improve our understanding of the observed physiological differences between the 2 ecotypes and potentially inform the development of novel interventions against lice infestations and louse-borne infectious diseases. Toward these goals, here we performed 16S rRNA gene amplicon sequencing to characterize the microbiomes of both head and body lice and identify patterns of interest among these communities. Our data reveal that head and body lice harbor limited but distinct communities of bacteria that include known intracellular endosymbionts ("Candidatus Riesia pediculicola"), extracellular bacteria that may be horizontally acquired from the host environment, and a number of taxa of known or potential public health significance. Notably, in body lice, the relative abundance of vertically transmitted endosymbionts is lower than in head lice, which is a significant driver of greater alpha diversity. Further, several differentially abundant non-endosymbiont taxa and differences in beta diversity were observed between head lice and body lice. These findings support the hypothesis that microbiome differences could contribute to the divergence between human louse ecotypes and underscore the need for future studies to better comprehend the acquisition and physiological roles of human lice microbiomes.
机译：人头虱和体虱（人虱）是被忽视的体外寄生虫。头虱在全世界儿童中继续流行，这些昆虫的抗药性使其治疗变得复杂。与此同时，在发展中国家最常见的体虱正在发达国家边缘化人群中重新流行。如今，微生物组正日益被认为是昆虫生理学的关键媒介。然而，除了少数几种细菌之外，人类虱子中的微生物群落仍然未知。了解头虱和体虱的微生物组群可以提高我们对这两种生态型之间观察到的生理差异的理解，并有可能为针对虱子感染和虱子传播传染病的新干预措施的开发提供信息。为了实现这些目标，我们在这里进行了16S rRNA基因扩增子测序，以表征头虱和体虱的微生物群，并确定这些群体中感兴趣的模式。我们的数据显示，头虱和体虱拥有有限但独特的细菌群落，其中包括已知的细胞内共生菌（Candidatus Riesia pediculicola）、可能从宿主环境水平获得的细胞外细菌，以及许多已知或潜在公共卫生意义的分类群。值得注意的是，在体虱中，垂直传播的内共生体的相对丰度低于头虱，这是更大α多样性的重要驱动因素。此外，在头虱和体虱之间观察到了几种不同数量的非内共生类群和β多样性差异。这些发现支持了微生物组差异可能导致人类虱子生态型之间差异的假设，并强调了未来研究的必要性，以更好地理解人类虱子微生物组的获取和生理作用。

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