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首页> 外文期刊>Journal of Parasitology >REGIONAL DISTRIBUTION OF A BRAIN-ENCYSTING PARASITE PROVIDES INSIGHT ON PARASITE-INDUCED HOST BEHAVIORAL MANIPULATION
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REGIONAL DISTRIBUTION OF A BRAIN-ENCYSTING PARASITE PROVIDES INSIGHT ON PARASITE-INDUCED HOST BEHAVIORAL MANIPULATION

机译：脑密封寄生虫的区域分布为寄生虫诱导的主体行为操纵提供了洞察力

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摘要

Some parasite species alter the behavior of intermediate hosts to promote transmission to the next host in the parasite's life cycle. This is the case for Euhaplorchis californiensis, a brain-encysting trematode parasite that causes behavioral changes in the California killifish (Fundulus parvipinnis). These manipulations increase predation by the parasite's final host, piscivorous marsh birds. The mechanisms by which E. californiensis achieves this manipulation remain poorly understood. As E. californiensis cysts reside on the surface of the killifish's brain, discerning regional differences in parasite distribution could indicate mechanisms for host control. In this study, we developed a method for repeated experimental infections. In addition, we measured brain-region specific density using a novel methodology to locate and quantify parasite infection. We show that E. californiensis cysts are non-randomly distributed on the fish brain, aggregating on the diencephalon/mesencephalon region (a brain area involved in controlling reproduction and stress coping) and the rhombencephalon (an area involved in controlling locomotion and basal physiology). Determining causal mechanisms behind this pattern of localization will guide future research examining the neurological mechanisms of parasite-induced host manipulation. These findings suggest that parasites are likely targeting the reproductive, monoaminergic, and locomotor systems to achieve host behavioral manipulation.
机译：一些寄生虫物种改变中间宿主的行为，以促进寄生虫生命周期中的下一宿主传播。加利福尼亚真单胞菌就是这种情况，它是一种大脑包囊性吸虫寄生虫，可导致加利福尼亚短鳍金枪鱼（Fundulus parvipinnis）的行为改变。这些操作增加了寄生虫的最终宿主——食鱼沼泽鸟的捕食。加州E.californiensis实现这种操纵的机制仍然知之甚少。由于加利福尼亚州E.Californiens囊肿位于杀人鱼的大脑表面，因此识别寄生虫分布的区域差异可能表明宿主控制机制。在这项研究中，我们开发了一种重复实验感染的方法。此外，我们使用一种新的方法测量了大脑区域的比密度，以定位和量化寄生虫感染。我们发现，加利福尼亚州E.Californiens囊肿非随机分布在鱼的大脑中，聚集在间脑/中脑区（一个参与控制繁殖和压力应对的大脑区域）和菱形脑（一个参与控制运动和基础生理的区域）。确定这种定位模式背后的因果机制将指导今后研究寄生虫诱导的宿主操纵的神经机制。这些发现表明，寄生虫可能以生殖系统、单胺能系统和运动系统为目标，实现宿主行为操纵。

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