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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Impaired Brachial Flow-Mediated Dilatation May Predict Symptomatic Intracranial Arterial Dissections
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Impaired Brachial Flow-Mediated Dilatation May Predict Symptomatic Intracranial Arterial Dissections

机译：血管流动介导的扩张受损可预测症状颅内动脉夹层

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Background and PurposeSpontaneous intracranial arterial dissections are characterized by the sudden disruption of the internal elastic lamina in the intracranial arteries. The purpose of our retrospective study was to investigate whether patients with nontraumatic intracranial arterial dissections had normal endothelial function. MethodsThe study included symptomatic patients with nontraumatic intracranial arterial dissections who underwent an endothelial function test. Controls were selected from headache patients matched for sex and age. Endothelial function was assessed using flow-mediated dilatation. We investigated patients’ ankle brachial index and pulse wave velocity to determine the degree of atherosclerosis. Patient characteristics, brachial flow-mediated dilatation, ankle brachial index, and pulse wave velocity were compared between the 2 groups. ResultsDuring the study period, there were 22 patients with nontraumatic intracranial arterial dissections matched with 22 controls. Clinical characteristics were compared between the groups. Although there were no significant differences in ankle brachial index or pulse wave velocity between the 2 groups, patients with intracranial arterial dissections had lower flow-mediated dilatation values than controls (median flow-mediated dilatation, 3.95% in dissection patients versus 7.3% in controls,P= .0035). Brachial flow-mediated dilatation was impaired in symptomatic patients with nontraumatic intracranial arterial dissections despite the normal ankle brachial index and pulse wave velocity. ConclusionsImpaired brachial flow-mediated dilatation is a probable predictor of intracranial arterial dissections.
机译：背景与目的自发性颅内动脉夹层的特征是颅内动脉内弹性层突然破裂。我们的回顾性研究旨在调查非创伤性颅内动脉夹层患者的内皮功能是否正常。方法本研究包括接受内皮功能测试的非创伤性颅内动脉夹层症状患者。对照组从性别和年龄相匹配的头痛患者中选择。采用流介导扩张法评估内皮功能。我们调查了患者的踝臂指数和脉搏波速度，以确定动脉粥样硬化的程度。比较两组患者特征、肱动脉血流介导的扩张、踝肱指数和脉搏波速度。结果在研究期间，22例非创伤性颅内动脉夹层患者与22例对照组匹配。比较两组患者的临床特征。尽管两组患者的踝臂指数或脉搏波速度没有显著差异，但颅内动脉夹层患者的血流介导扩张值低于对照组（中值血流介导扩张，夹层患者为3.95%，对照组为7.3%，P=0.0035）。尽管踝臂指数和脉搏波速度正常，但有症状的非外伤性颅内动脉夹层患者的肱动脉血流介导的扩张功能受损。结论肱动脉血流介导的扩张可能是颅内动脉夹层的预测因子。

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