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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Call to Action: SARS-CoV-2 and CerebrovAscular DisordErs (CASCADE)
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Call to Action: SARS-CoV-2 and CerebrovAscular DisordErs (CASCADE)

机译：呼吁采取行动：SARS-COV-2和脑血管障碍（级联）

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Background and purpose: The novel severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2), now named coronavirus disease 2019 (COVID-19), may change the risk of stroke through an enhanced systemic inflammatory response, hypercoagula-ble state, and endothelial damage in the cerebrovascular system. Moreover, due to the current pandemic, some countries have prioritized health resources towards COVID-19 management, making it more challenging to appropriately care for other potentially disabling and fatal diseases such as stroke. The aim of this study is to identify and describe changes in stroke epidemiological trends before, during, and after the COVID-19 pandemic. Methods: This is an international, multicenter, hospi-tal-based study on stroke incidence and outcomes during the COVID-19 pandemic. We will describe patterns in stroke management, stroke hospitalization rate, and stroke severity, subtype (ischemic/hemorrhagic), and outcomes (including in-hos-pital mortality) in 2020 during COVID-19 pandemic, comparing them with the cor-responding data from 2018 and 2019, and subsequently 2021. We will also use an interrupted time series (ITS) analysis to assess the change in stroke hospitalization rates before, during, and after COVID-19, in each participating center. Conclusion: The proposed study will potentially enable us to better understand the changes in stroke care protocols, differential hospitalization rate, and severity of stroke, as it pertains to the COVID-19 pandemic. Ultimately, this will help guide clinical-based policies surrounding COVID-19 and other similar global pandemics to ensure that management of cerebrovascular comorbidity is appropriately priori-tized during the global crisis. It will also guide public health guidelines for at-risk populations to reduce risks of complications from such comorbidities. (c) 2020 Elsevier Inc. All rights reserved.
机译：背景和目的：新型严重急性呼吸综合征冠状病毒2（SARS-Cov-2），现命名为2019年冠状病毒病（COVID-19），可能通过增强全身炎症反应、高凝状态和脑血管系统内皮损伤来改变中风风险。此外，由于2019冠状病毒疾病的流行，一些国家将卫生资源优先纳入COVID-19的管理，使其更具挑战性地适当地照顾其他潜在的致残和致命疾病，如中风。本研究的目的2019冠状病毒疾病流行之前、期间和之后，确定和描述卒中流行病学趋势的变化。方法：这是2019冠状病毒疾病流行期间国际上、多中心、以医院为基础的卒中发病率和预后的研究。我们将描述中风2019冠状病毒疾病的管理模式、卒中住院率和卒中严重程度、亚型（缺血性/出血）和预后（包括HOS死亡率），将其与2018和2019的COR应答数据进行比较，随后为2021。我们也将使用2019冠状病毒疾病的分析，评估每个参与中心之前、期间和之后的卒中住院率的变化。结论：2019冠状病毒疾病的发生率、卒中住院率、严重程度等因素的变化，可能与COVID-19流行病有关。最终，2019冠状病毒疾病和其他类似的全球流行病的临床政策将有助于确保在全球危机期间脑血管共病的管理适当地预先被纳入。它还将指导高危人群的公共卫生指南，以减少此类共病并发症的风险。（c） 2020爱思唯尔公司版权所有。

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