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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Left Atrial Appendage Morphology and Embolic Stroke of Undetermined Source: A Cross-Sectional Multicenter Pilot Study
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Left Atrial Appendage Morphology and Embolic Stroke of Undetermined Source: A Cross-Sectional Multicenter Pilot Study

机译：左心房阑尾形态和未确定来源的栓塞卒中：横断面多中心试点研究

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Background: The left atrial appendage (LAA) is the main source of thrombus in atrial fibrillation, and there is an association between non-chicken wing (NCW) LAA morphology and stroke. We hypothesized that the prevalence of NCW LAA morphology would be higher among patients with cardioembolic (CE) stroke and embolic stroke of undetermined source (ESUS) than among those with noncardioembolic stroke (NCS). Methods: This multicenter retrospective pilot study included consecutive patients with ischemic stroke from 3 comprehensive stroke centers who previously underwent a qualifying chest computed tomography (CT) to assess LAA morphology. Patients underwent inpatient diagnostic evaluation for ischemic stroke, and stroke subtype was determined based on ESUS criteria. LAA morphology was determined using clinically performed contrast enhanced thin-slice chest CT by investigators blinded to stroke subtype. The primary predictor was NCW LAA morphology and the outcome was stroke subtype (CE, ESUS, NCS). Results: We identified 172 patients with ischemic stroke who had a clinical chest CT performed. Mean age was 70.1 +/- 14.3 years and 51.7% were male. Compared with patients with NCS, the prevalence of NCW LAA morphology was higher in patients with CE stroke (58.7% versus 46.3%, P = .1) and ESUS (58.8% versus 46.3%, P = .2), but this difference did not achieve statistical significance. Conclusion: The prevalence of NCW LAA morphology may be similar in patients with ESUS and CE, and may be higher than that in those with NCS. Larger studies are needed to confirm these associations.
机译：背景：左心耳（LAA）是心房颤动中血栓的主要来源，非鸡翅（NCW）左心耳形态与中风有关联。我们假设心源性栓塞（CE）卒中和来源不明的栓塞性卒中（ESUS）患者的NCW LAA形态学患病率高于非心源性栓塞性卒中（NCS）患者。方法：这项多中心回顾性初步研究包括来自3个综合卒中中心的连续缺血性卒中患者，他们之前接受了合格的胸部计算机断层扫描（CT）以评估LAA形态学。患者接受缺血性卒中住院诊断评估，并根据ESUS标准确定卒中亚型。LAA的形态是由不了解中风亚型的研究人员使用临床上进行的对比增强薄层胸部CT确定的。主要预测因素是NCW LAA形态，结果是中风亚型（CE、ESUS、NCS）。结果：我们确定172名缺血性中风患者进行了临床胸部CT检查。平均年龄为70.1+/-14.3岁，51.7%为男性。与NCS患者相比，CE卒中患者（58.7%对46.3%，P=0.1）和ESUS患者（58.8%对46.3%，P=0.2）的NCW LAA形态学患病率更高，但这一差异没有达到统计学意义。结论：ESUS和CE患者中NCW LAA形态的患病率可能相似，并且可能高于NCS患者。需要更大规模的研究来证实这些关联。

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