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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Prevalence and Associated Risk Factors of Cerebral Microbleeds in Egyptian Patients with Acute Ischemic Stroke and Atrial Fibrillation
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Prevalence and Associated Risk Factors of Cerebral Microbleeds in Egyptian Patients with Acute Ischemic Stroke and Atrial Fibrillation

机译：埃及急性缺血性卒中和心房颤动患者脑微微患者的患病率和相关危险因素

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Background: Few studies addressed the prevalence of cerebral microbleeds (CMB) and associated risk factor profile in Egyptian ischemic cerebral stroke patients with atrial fibrillation (AF). Methods: The prevalence of CMB was estimated in 150 cases of AF ischemic stroke patients and compared to the prevalence in 150 age- and sex-matched controls of ischemic stroke patients without AF. CMB-associated risk factors were identified by comparing AF ischemic stroke patients with and without CMB. All participants were subjected to complete general, neurological examination, and magnetic resonance imaging. Results: The prevalence of CMBs in ischemic stroke with and without AF was 40.7% and 49.3%, respectively. Age, hypertension, diabetes mellitus, past history of stroke, antiplatelet, anticoagulant, National Institutes of Health Stroke Scale, CHA(2)DS(2)VASc, and white matter lesions (WML) were significant risk factors associated with CMB on univariate analysis. On multivariable logistic regression analysis, age (odds ratio [OR] 1.1, confidence interval [CI]1.02-1.13), hypertension (OR 3.2, CI 1.19-8.81), anticoagulant (OR 3.3, CI 1.17-9.40), and WML (OR 9.6, CI 3.49-26.3) were the only independent risk factors associated with the presence of CMBs. Conclusions: AF in ischemic stroke patients was not associated with higher prevalence of CMBs. Old age, hypertension, anticoagulant treatment, and WML were the independent risk factors associated with CMB in AF ischemic stroke patients. Our results suggest that elderly hypertensive AF ischemic stroke patients maintained on anticoagulant therapy should be screened for the incidence of CMBs and monitored regularly for the development of intracerebral hemorrhage.
机译：背景：很少有研究涉及埃及缺血性脑卒中合并心房颤动（AF）患者脑微出血（CMB）的患病率和相关风险因素。方法：在150例AF缺血性卒中患者中估计CMB的患病率，并与150例年龄和性别匹配的无AF缺血性卒中患者的患病率进行比较。通过比较有和无CMB的AF缺血性卒中患者，确定CMB相关的危险因素。所有参与者都接受了全面的全身检查、神经学检查和磁共振成像。结果：有房颤和无房颤的缺血性卒中患者CMBs的患病率分别为40.7%和49.3%。单变量分析显示，年龄、高血压、糖尿病、既往卒中史、抗血小板、抗凝剂、美国国立卫生研究院卒中量表、CHA（2）DS（2）VASc和白质病变（WML）是与CMB相关的重要危险因素。在多变量逻辑回归分析中，年龄（优势比[OR]1.1，置信区间[CI]1.02-1.13）、高血压（OR 3.2，CI 1.19-8.81）、抗凝剂（OR 3.3，CI 1.17-9.40）和WML（OR 9.6，CI 3.49-26.3）是与CMBs存在相关的唯一独立危险因素。结论：缺血性卒中患者房颤与CMBs的高患病率无关。老年、高血压、抗凝治疗和WML是与房颤缺血性卒中患者CMB相关的独立危险因素。我们的结果表明，接受抗凝治疗的老年高血压性房颤缺血性卒中患者应筛查CMBs的发生率，并定期监测脑出血的发展。

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