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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >The Association of Growth Differentiation Factor-15 Gene Polymorphisms with Growth Differentiation Factor-15 Serum Levels and Risk of Ischemic Stroke
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The Association of Growth Differentiation Factor-15 Gene Polymorphisms with Growth Differentiation Factor-15 Serum Levels and Risk of Ischemic Stroke

机译：生长分化因子-15基因多态性与生长分化因子-15血清水平和缺血性卒中风险的关联

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Background Current evidence shows that growth differentiation factor-15 (GDF-15) plays an important role in the progression of ischemic stroke (IS). The aim of this study was to investigate the association between 3 single-nucleotide polymorphisms of the GDF-15 gene and IS susceptibility in the Chinese population. Materials and Methods The study subjects comprised 601 Chinese individuals, including 298 stroke patients and 303 age- and gender-matched healthy controls. The polymorphisms were measured using snapshot single-nucleotide polymorphism genotyping assays and confirmed by sequencing. Serum GDF-15 (sGDF-15) levels were measured by enzyme-linked immunosorbent assay. Results The distribution of rs1804826G/T polymorphism was significant different between the 2 groups ( P ??.05). Compared with the rs1804826 G allele, the rs1804826 T allele was significantly associated with an increased risk of IS ( P ??.05). Haplotype analyses showed that the T-T-G haplotype was significantly associated with an increased risk of IS (odds ratio?=?1.671, 95% confidence interval?=?1.231-2.268; P ?=?.001). Compared with the normal controls, the sGDF-15 levels were significantly increased in stroke patients ( P ??.001). Besides, patients carrying rs1804826 GT/TT genotypes had higher sGDF-15 levels compared with those carrying GG genotypes ( P? ?.05). Conclusions The GDF-15 gene rs1804826G/T polymorphism and sGDF-15 levels are associated with IS in the Chinese population. Our data indicate that the GDF-15 gene may play a role in the development of IS. ]]>
机译：背景目前的证据表明，生长分化因子-15（GDF-15）在缺血性卒中（IS）的进展中起着重要作用。本研究的目的是调查中国人群中GDF-15基因的3个单核苷酸多态性与IS易感性之间的关系。材料与方法研究对象包括601名中国人，包括298名中风患者和303名年龄和性别匹配的健康对照。采用snapshot单核苷酸多态性基因分型法测定多态性，并通过测序确认。采用酶联免疫吸附法测定血清GDF-15（sGDF-15）水平。结果rs1804826G/T多态性在两组间的分布有显著性差异（P＜0.05）。与rs1804826 G等位基因相比，rs1804826 T等位基因与IS风险增加显著相关（P？；0.05）。单倍型分析显示T-T-G单倍型与IS风险增加显著相关（优势比？=1.671，95%置信区间？=1.231-2.268；P？=0.001）。与正常对照组相比，脑卒中患者的sGDF-15水平显著升高（P＜0.001）。此外，与携带GG基因型的患者相比，携带rs1804826 GT/TT基因型的患者的sGDF-15水平更高（P？；05）。结论中国人群中GDF-15基因rs1804826G/T多态性和sGDF-15水平与IS相关。我们的数据表明，GDF-15基因可能在IS的发展中发挥作用。]]>

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