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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Low Muscle Mass is Associated with Walking Function in Patients with Acute Ischemic Stroke
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Low Muscle Mass is Associated with Walking Function in Patients with Acute Ischemic Stroke

机译：低肌肉质量与急性缺血性卒中患者的行走功能有关

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Background: Muscle mass might be a possible predictor for walking function in patients with stroke; however, evidence is limited. Objective: To investigate whether skeletal muscle mass is associated with walking function at discharge during the acute phase. Methods: In this observational cohort study, we assessed skeletal muscle mass in patients with acute ischemic stroke using the noninvasive and portable multifrequency bio-impedance device. This device can easily be used in bedridden patients. Appendicular skeletal muscle mass was converted to skeletal muscle index (SMI) standardizing by height squared (kg/m(2)). The primary outcome was walking function assessed by the modified Rankin Scale score at acute phase hospital discharge. Logistic regression analysis was used to determine the association between skeletal muscle mass and walking function. Results: Of the 107 patients enrolled, low SMI (SMI: male <7.0 kg/m(2), female <5.7 kg/m(2)) was identified in 29.9% (19.7% in men, 48.6% in women). Logistic regression analysis showed that low SMI [OR: 4.02, 95% confidence interval (CI): 1.38-11.7, p = 0.001] independently associated with walking function at discharge. Further, patients with mild and moderate severity had significant difficulty in walking when they had low SMI (p = 0.039). Conclusions: Low skeletal muscle mass at the onset of ischemic stroke is an independent predictor of walking function at discharge during the acute phase. Our findings highlight the importance of detecting skeletal muscle mass in patients with acute ischemic stroke.
机译：背景：肌肉质量可能是脑卒中患者步行功能的一个可能预测指标；然而，证据有限。目的：探讨急性期出院时骨骼肌质量是否与步行功能有关。方法：在这项观察性队列研究中，我们使用无创便携式多频生物阻抗仪评估了急性缺血性卒中患者的骨骼肌质量。这种设备可以很容易地用于卧床不起的病人。根据身高平方（kg/m（2））将阑尾骨骼肌质量转换为骨骼肌指数（SMI）。主要结果是在急性期出院时通过改良的Rankin量表评分评估步行功能。Logistic回归分析用于确定骨骼肌质量与步行功能之间的关系。结果：在107例入选患者中，29.9%的患者出现了低SMI（SMI：男性<7.0 kg/m2，女性<5.7 kg/m2）（男性19.7%，女性48.6%）。逻辑回归分析显示，低SMI[OR:4.02，95%置信区间（CI）：1.38-11.7，p=0.001]与出院时的步行功能独立相关。此外，轻度和中度严重的患者在SMI较低时有明显的行走困难（p=0.039）。结论：缺血性卒中发病时骨骼肌质量较低是急性期出院时步行功能的独立预测因素。我们的研究结果强调了检测急性缺血性中风患者骨骼肌质量的重要性。

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