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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >The Influence of Physical Activity on Cavernous Malformation Hemorrhage
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The Influence of Physical Activity on Cavernous Malformation Hemorrhage

机译：身体活动对海绵状畸形出血的影响

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Background and Aim: Cavernous malformations are low-flow vascular malformations of the central nervous system. Brainstem location and prior hemorrhage increase future hemorrhage risk. We sought to determine the influence of physical activity on hemorrhage risk. Methods: Consecutive patients with radiologically confirmed cavernous malformations participated in a prospective registry with structured, baseline interviews, surveys, and examinations. Patients were asked about unusual events prior to initial clinical presentation. Medical records and MRIs were reviewed. Patients were surveyed about their physical activity after receiving their diagnosis. Annual follow-up surveys to patients ascertained new hemorrhages. Follow-up terminated at last follow-up, hemorrhage, surgery, or death. Univariate analysis assessed the risk of physical activities on prospective hemorrhage. Results: Of 195 patients, 117 (60%) were female. Median diagnosis age was 41 years. After diagnosis, 103 (52.8%) patients returned the physical activity survey (cerebral n = 100; spine n = 3). Over 539.4 patient years, 23 had a prospective hemorrhage. Five patients were removed from analysis because they had less than 6 weeks of physical-activity exposure before censor. The remaining 98 had no difference in prospective hemorrhage risk than those patients participating greater than or equal to 3 times monthly in walking, running, greater than 20-pound or less than 20-pound weight lifting, or noncontact sports. Few (n = 5) reported contact-sport participation, scuba diving (n = 2), or high-altitude climbing (n = 1) greater than 3 times monthly. Conclusions: Aerobic activity and noncontact sports do not increase hemorrhage risk in cerebral cavernous malformation; patients should not be restricted. Less is known about contact sports, high-altitude climbing, scuba diving, and those with spinal-cord cavernous malformation.
机译：背景与目的：海绵状血管畸形是中枢神经系统的低流量血管畸形。脑干位置和之前的出血会增加未来的出血风险。我们试图确定体力活动对出血风险的影响。方法：连续的经放射学证实的海绵状畸形患者参与前瞻性登记，进行结构化基线访谈、调查和检查。患者在首次临床表现之前被问及异常事件。检查病历和磁共振成像。患者在接受诊断后接受了关于他们的体力活动的调查。对患者的年度随访调查确定了新的出血。随访在最后一次随访、出血、手术或死亡时终止。单变量分析评估了预期出血的体力活动风险。结果：195例患者中，117例（60%）为女性。中位诊断年龄为41岁。诊断后，103名（52.8%）患者恢复了体力活动调查（大脑n=100；脊柱n=3）。在539.4个患者年中，23人有预期出血。五名患者被排除在分析之外，因为他们在审查之前的体力活动暴露时间不足6周。剩下的98名患者在预期出血风险方面与每月步行、跑步、20磅以上或20磅以下举重或非接触性运动超过或等于3次的患者没有差异。很少有（n=5）报告每月接触性运动参与、潜水（n=2）或高空攀爬（n=1）超过3次。结论：有氧运动和非接触性运动不会增加脑海绵状血管畸形的出血风险；患者不应受到限制。关于接触性运动、高空攀爬、潜水和脊髓海绵状畸形的人知之甚少。

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