...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Pathophysiology, Mechanism, and Outcome of Ischemic Stroke in Cancer Patients
【24h】

Pathophysiology, Mechanism, and Outcome of Ischemic Stroke in Cancer Patients

机译：癌症患者缺血性卒中的病理生理学，机制和结果

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objectives: The purpose of this study is to assess the risk factors, biomarkers of stroke, mechanism, and outcomes of cerebral infarction among cancerous diseases. Materials & Methods: 156 patients presented by acute ischemic stroke were divided into two groups: the first group included 78 ischemic stroke patients associated with different types of cancer and the second group (control group) included 78 ischemic stroke patients not associated with cancer. Both groups were compared regarding the risk factors, previous thrombotic activity, subtypes, biomarkers of stroke, and outcomes. Results: Cancer patients presented by acute ischemic stroke were accompanied by a significantly less incidence of diabetes mellitus, hypertension, dyslipidemia, and coronary heart disease, and atrial fibrillation than non-cancer patients (P < 0.001). While, levels of biomarkers of inflammation like erythrocyte sedimentation rate and C-reactive protein, and stroke biomarkers like fibrinogen, and D-dimer, all together were highly elevated in cancerous disease group of patients (P < 0.01). The prevalence of deep vein thrombosis, pulmonary embolism, and myocardial infarction was significantly higher in patients with cancer than in control patients without cancer (P = 0.008, P < 0.01 and P < 0.01 respectively). The most common stroke etiologies were atherosclerosis of large arteries and stroke of undetermined cause in a cancerous group of patients. Cancer patients were accompanied by significant higher mortality rate (P = 0.005), and more disability as determined by mRS (P < 0.005) Conclusions: Pathophysiology and mechanism of ischemic stroke in cancerous disease patients were due to different risk factors, biomarkers of stroke, and subtypes in comparison with non-cancerous cases.
机译：目的：本研究旨在评估癌症疾病中脑梗死的危险因素、卒中生物标志物、发病机制和预后。材料与方法：156例急性缺血性脑卒中患者被分为两组：第一组包括78例与不同类型癌症相关的缺血性脑卒中患者，第二组（对照组）包括78例与癌症无关的缺血性脑卒中患者。比较两组患者的危险因素、既往血栓性活动、亚型、卒中生物标志物和预后。结果：以急性缺血性卒中为首发症状的癌症患者与非癌症患者相比，糖尿病、高血压、血脂异常、冠心病和心房颤动的发生率显著降低（P<0.001）。而炎症生物标志物如红细胞沉降率和C反应蛋白，以及中风生物标志物如纤维蛋白原和D-二聚体的水平在癌症患者组中均高度升高（P<0.01）。癌症患者深静脉血栓形成、肺栓塞和心肌梗死的患病率显著高于非癌症对照患者（分别为P=0.008、P<0.01和P<0.01）。最常见的中风病因是大动脉动脉粥样硬化和癌症患者中病因不明的中风。癌症患者的死亡率显著较高（P=0.005），mRS测定的致残率也较高（P<0.005）。结论：与非癌症患者相比，癌症患者缺血性卒中的病理生理学和机制是由不同的危险因素、卒中生物标志物和亚型引起的。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号