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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Sex differences of ischemic stroke in young adults-A single-center Chinese cohort study
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Sex differences of ischemic stroke in young adults-A single-center Chinese cohort study

机译：年轻成年人缺血性中风的性差异 - 单中心中国队列研究

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摘要

Background and Objective: Stroke at a young age is a societal challenge with a rising incidence. Our aim was to investigate sex differences in risk factors, etiology, and diagnostic process of ischemic stroke in Chinese young adults. Methods: We retro-spectively recruited 411 consecutive patients with first-ever ischemic stroke who were 18 to 50 years of age (mean age, 38.2 +/- 8.1 years, women 31.4%), admitted to Peking Union Medical College Hospital from 2007 to 2018. Sex differences in demo-graphics, risk factors, etiology, and diagnostic testing were analyzed. Results: Females were significantly younger than males (36.9 versus 38.7 years, P<0.05). Hypertension (43.0%), smoking (41.1%), hyperlipidemia (37.2%), and hyperhomocysteinemia (27.9%) were common risk factors, statistically higher among males than females (P<0.05). Stroke etiology showed a significant sex differ-ence that large-artery atherosclerosis and small-vessel diseases were more common among males than females (48.6% versus 19.4%, P<0.001; 9.9% versus 3.1%, P<0.05, respectively). Stroke of other determined etiology was more common among females (50.4% versus 19.1%, P<0.001). Relevant abnormality rates were higher among females on screening for autoimmune diseases and thrombophilia (23.3% versus 11.1%, P<0.05 and 50.0% versus 16.7%, P<0.001, respectively). Conclusions: A high rate of the traditional stroke risk factors and etiological subtype of large artery atherosclerosis in males were found, as well as prominent sex differ-ences in relevant diagnostic testing abnormality rates, providing useful information for developing sex-specific strategies in stroke evaluation and prevention in young adults.
机译：背景和目的：年轻时中风是一种社会挑战，发病率不断上升。我们的目的是调查中国年轻人缺血性中风的危险因素、病因和诊断过程中的性别差异。方法：我们回顾性招募了411例首次缺血性中风患者，他们的年龄在18岁至50岁之间（平均年龄38.2+/-8.1岁，女性31.4%），于2007年至2018年入住北京协和医院。分析了演示图、危险因素、病因和诊断测试中的性别差异。结果：女性明显比男性年轻（36.9岁对38.7岁，P<0.05）。高血压（43.0%）、吸烟（41.1%）、高脂血症（37.2%）和高同型半胱氨酸血症（27.9%）是常见的危险因素，男性高于女性（P<0.05）。中风病因学显示出显著的性别差异，即大动脉动脉粥样硬化和小血管疾病在男性中比女性更常见（分别为48.6%和19.4%，P<0.001；9.9%和3.1%，P<0.05）。其他确定病因的中风在女性中更常见（50.4%对19.1%，P<0.001）。女性自身免疫性疾病和血栓形成相关异常率较高（分别为23.3%和11.1%，P<0.05和50.0%和16.7%，P<0.001）。结论：男性大动脉动脉粥样硬化的传统卒中危险因素和病因亚型的发生率较高，相关诊断检测异常率存在显著的性别差异，为制定针对年轻人的卒中评估和预防策略提供了有用的信息。

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