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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Asymptomatic Striatocapsular slit-like Hemorrhage as a Severity Marker in Patients with Hypertensive Angiopathy
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Asymptomatic Striatocapsular slit-like Hemorrhage as a Severity Marker in Patients with Hypertensive Angiopathy

机译：无症状的纹状体狭缝样出血，作为高血压血管病患者的严重程度标志物

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Background: Concomitant asymptomatic striatocapsular slit-like hemorrhage (SSH) is occasionally found in patients of spontaneous intracerebral hemorrhage (ICH), but was seldomly described in the literature. In this study, we described the clinicoradiological features of asymptomatic SSH in ICH patients with hypertensive microangiopathy. Methods and Results: 246 patients with strictly deep or mixed deep and lobar ICH/microbleeds were included. SSH was defined as hypointense lesions involving the lateral aspect of lentiform nucleus or external capsule in slit shape (>1.5 cm) on susceptibility-weighted imaging without history of associated symptoms. Demographics and neuroimaging markers were compared between patients with SSH and those without. Patients with SSH (n=24, 10%) and without SSH had comparable age (62.0 +/- 12.6 vs. 62.3 +/- 13.5, p = 0.912) and vascular risk factor profiles including the diagnosis of chronic hypertension, diabetes, and dyslipidemia (all p>0.05). SSH was associated with more common lobar microbleeds (79.2% vs 48.2%, p = 0.005), lacunes (75% vs. 41.4%, p = 0.002) and higher white matter hyperintensity (WMH) volumes (24.1 [10.4-46.3] vs. 13.9 [7.0-24.8] mL, p = 0.012) on MRI, as well as more frequent left ventricular hypertrophy (LVH) (50.0% vs. 20.5%, p = 0.004) and albuminuria (41.7% vs. 19.4%, p = 0.018). In multi variable analyses, SSH remains independently associated with LVH (p = 0.017) and albuminuria (p = 0.032) after adjustment for age, sex, microbleed, lacune and WMH volume. Conclusions: Asymptomatic SSH is associated with more severe cerebral small vessel disease-related change on brain MRI, and hypertensive cardiac and renal injury, suggesting a more advanced stage of chronic hypertension. (c) 2020 Elsevier Inc. All rights reserved.
机译：背景：自发性脑出血（ICH）患者偶尔会出现伴发的无症状纹状体包膜狭缝样出血（SSH），但文献中描述较少。在这项研究中，我们描述了伴有高血压微血管病的ICH患者中无症状SSH的临床和生物学特征。方法和结果：纳入246例重度深部或混合性深叶脑出血/微出血患者。SSH被定义为在敏感性加权成像上，涉及豆状核侧面或狭缝状外囊（>1.5 cm）的低信号病变，无相关症状史。比较SSH患者和非SSH患者的人口统计学和神经影像学指标。患有SSH（n=24，10%）和未患有SSH的患者具有相似的年龄（62.0+/-12.6 vs.62.3+/-13.5，p=0.912）和血管风险因素特征，包括慢性高血压、糖尿病和血脂异常的诊断（均p>0.05）。SSH与更常见的大叶微出血（79.2%比48.2%，p=0.005）、腔隙（75%比41.4%，p=0.002）和更高的白质高强度（WMH）体积（24.1[10.4-46.3]比13.9[7.0-24.8]毫升，p=0.012）以及更频繁的左心室肥厚（50.0%比20.5%，p=0.004）和蛋白尿（41.7%比19.4%，p=0.018）有关。在多变量分析中，调整年龄、性别、微出血、腔隙和WMH体积后，SSH仍然与LVH（p=0.017）和蛋白尿（p=0.032）独立相关。结论：无症状的SSH与脑部MRI上更严重的脑小血管疾病相关改变以及高血压心脏和肾脏损伤有关，提示慢性高血压处于更晚期。（c） 2020爱思唯尔公司版权所有。

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