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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Dynamic Cerebral Autoregulation in Preclinical Atherosclerotic Cardiovascular Disease
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Dynamic Cerebral Autoregulation in Preclinical Atherosclerotic Cardiovascular Disease

机译：临床前动脉粥样硬化心血管疾病中的动态脑自身

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Objective: The influence of atherosclerotic cardiovascular disease (ASCVD) on cerebral blood flow control is not well known. The aim of this study was to investigate the asso-ciation between cardiovascular function and dynamic cerebral autoregulation (dCA) in patients with preclinical ASCVD. Methods: A total of 44 participants aged 26-76 years were divided into low-and high-risk groups according to the China assessment of ASCVD risk. The cardiac function was assessed by echocardiography. The beat-to-beat blood pressure and cerebral blood flow velocity were measured at rest. Spectral and transfer function analyses were used to calculate cerebral and systemic hemodynamic variability and to estimate dCA metrics. Results: There were no group differences in beat-to-beat heart rate, blood pressure, and cerebral blood flow velocity variability nor the ejection fraction, E/A and E'/A'. The dCA phase at very low frequency was reduced in the high-risk group (P = .03). Moreover, the dCA phase and E'/A' were negatively correlated with age, and dCA phase was positively correlated with E'/A' within the high-risk group (r2= .517, P < .01). Conclusions: These findings suggest that advancing age, particularly in the high-risk ASCVD group, impairs cerebral blood flow control and cardiac diastolic function which are correlated with each other and may interplay under the effects of ASCVD risk factors.
机译：目的：动脉粥样硬化性心血管疾病（ASCVD）对脑血流控制的影响尚不清楚。本研究旨在探讨临床前ASCVD患者心血管功能与动态脑自动调节（dCA）之间的关系。方法：根据中国ASCVD风险评估，将44名26-76岁的参与者分为低风险组和高风险组。超声心动图评价心功能。在休息时测量每搏血压和脑血流速度。光谱和传递函数分析用于计算脑和全身血流动力学变异性，并估计dCA指标。结果：两组之间的心率、血压、脑血流速度变异性、射血分数、E/A和E'/A均无差异。高危组的dCA期频率极低（P=0.03）。此外，在高危人群中，dCA期和E'/A'与年龄呈负相关，dCA期与E'/A'呈正相关（r2=0.517，P<0.01）。结论：这些研究结果表明，年龄的增长，尤其是高危ASCVD组，会损害脑血流控制和心脏舒张功能，这两者相互关联，并可能在ASCVD危险因素的影响下相互作用。

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