首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Cerebral Venous Sinus Thrombosis in COVID-19 Infection: A Case Series and Review of The Literature
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Cerebral Venous Sinus Thrombosis in COVID-19 Infection: A Case Series and Review of The Literature

机译:Covid-19感染中脑静脉血栓形成:案例系列和文献综述

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SARS-CoV-2, the virus responsible for novel Coronavirus (COVID-19) infection, has recently been associated with a myriad of hematologic derangements; in particular, an unusually high incidence of venous thromboembolism has been reported in patients with COVID-19 infection. It is postulated that either the cytokine storm induced by the viral infection or endothelial damage caused by viral binding to the ACE-2 receptor may activate a cascade leading to a hypercoaguable state. Although pulmonary embolism and deep venous thrombosis have been well described in patients with COVID-19 infection, there is a paucity of literature on cerebral venous sinus thrombosis (cVST) associated with COVID-19 infection. cVST is an uncommon etiology of stroke and has a higher occurrence in women and young people. We report a series of three patients at our institution with confirmed COVID-19 infection and venous sinus thrombosis, two of whom were male and one female. These cases fall outside the typical demographic of patients with cVST, potentially attributable to COVID-19 induced hypercoaguability. This illustrates the importance of maintaining a high index of suspicion for cVST in patients with COVID-19 infection, particularly those with unexplained cerebral hemorrhage, or infarcts with an atypical pattern for arterial occlusive disease.
机译:新型冠状病毒(2019冠状病毒疾病)的SARS COV-2最近与多种血液紊乱有关;特别是,在2019冠状病毒疾病患者中,静脉血栓栓塞发生率异常高。据推测,病毒感染引起的细胞因子风暴或病毒与ACE-2受体结合引起的内皮损伤都可能激活级联反应,导致高凝状态。2019冠状病毒疾病2019冠状病毒疾病患者中,肺栓塞和深静脉血栓形成的研究已很好地报道,但与COVID-19感染相关的脑静脉窦血栓形成(CVST)文献尚不多见。cVST是一种罕见的中风病因,在女性和年轻人中发生率较高。2019冠状病毒疾病,静脉窦血栓形成,其中男三例,女1例。C2019冠状病毒疾病患者的典型人群,可能是COVID-19诱导的高凝状态。这说明2019冠状病毒疾病患者,尤其是不明原因脑出血患者,或动脉闭塞性疾病的非典型型梗塞,对CVST保持高怀疑的重要性。

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