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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >An Embolic Stroke in a Patient With PROC p.Lys193del
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An Embolic Stroke in a Patient With PROC p.Lys193del

机译：患者患者患者患者患者193del

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摘要

We report a 58-year-old woman who suddenly developed brain infarction with weakness of the left lower extremity and left perioral dysesthesia during postoperative tamoxifen therapy for breast cancer and prednisolone therapy for rheumatoid arthritis. Diffusion-weighted images detected multiple areas of hyperintensity in the posterior circulation system of the brain. Despite extensive examinations, we could not identify any embolic sources except hypoplasia of the right vertebral artery. We found decreased activity of protein C against its antigen level (activity: 59% versus antigen: 122%) with enhanced activity of coagulation factor VIII (178%) and von Willebrand factor (285%). DNA sequencing identified trinucleotide deletion of the PROC gene leading to 1 amino acid deletion at Lys-193 (p.Lys193del). We speculate that the PROC gene polymorphism may have participated in tamoxifen- and prednisolone- associated hypercoagulable state, leading to development of an embolic stroke in this patient.
机译：我们报告一位58岁女性，在乳腺癌术后他莫昔芬治疗和类风湿性关节炎术后泼尼松龙治疗期间突然发生脑梗塞，伴有左下肢无力和左口周感觉障碍。扩散加权成像检测到大脑后循环系统的多个高强度区域。尽管进行了广泛的检查，但除了右椎动脉发育不良外，我们无法确定任何栓塞来源。我们发现，蛋白C的活性降低（活性：59%，抗原：122%），凝血因子VIII（178%）和血管性血友病因子（285%）的活性增强。DNA测序鉴定出PROC基因的三核苷酸缺失导致Lys-193（p.Lys193del）的1个氨基酸缺失。我们推测PROC基因多态性可能参与了他莫昔芬和泼尼松龙相关的高凝状态，导致该患者发生栓塞性中风。

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