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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Determining Maximal Tolerable Aerobic Training Intensity in the Acute Phase after Stroke: a Novel Dose Ranging Trial Protocol
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Determining Maximal Tolerable Aerobic Training Intensity in the Acute Phase after Stroke: a Novel Dose Ranging Trial Protocol

机译：中风后测定急性期的最大可耐受性的有氧训练强度：一种新型剂量测距试验方案

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Introduction: There is strong evidence that cardiorespiratory fitness (CRF) training improves fitness and mobility after stroke. Despite the large number of studies, the most efficacious dose is yet to be determined. Furthermore, the safety of early post-stroke training, while theoretically beneficial, remains uncertain. The aim of this study is to determine the maximum safe and tolerable intensity of CRF training early post-stroke. Methods: This is a stratified (low to moderate exercise capacity), Phase I, 5+5 dose ranging trial protocol. Participants will be recruited within one month post-stroke and stratified by their exercise-capacity (i.e. low and moderate capacity). Cohorts of five participants will perform 12 interval-based training sessions for four-weeks at a pre-determined target-intensity. The intensity will increase in each consecutive cohort, in each stratum according to pre-defined rules until the maximum safe and tolerable intensity is reached, as determined by the occurrence of dose-limiting events and occurrence of adverse events. Dose-limiting events are defined as symptoms indicative of over-training including pain and inability to perform usual activities. Study Outcome: Maximum safe and tolerable intensity of CRF training in stroke survivors with low and moderate exercise capacity. Discussion: This study is a first step in the systematic development of a CRF training intervention. We believe similar dose ranging designs may be useful for development of other rehabilitation interventions in different study populations.
机译：导言：有强有力的证据表明，心肺健康（CRF）训练可以改善中风后的健康和活动能力。尽管进行了大量研究，但最有效的剂量仍有待确定。此外，中风后早期训练的安全性虽然在理论上是有益的，但仍不确定。本研究的目的是确定卒中后早期CRF训练的最大安全和可耐受强度。方法：这是一项分层（低至中等运动能力）I期5+5剂量范围试验方案。参与者将在中风后一个月内招募，并根据其运动能力（即低和中等能力）进行分层。由五名参与者组成的队列将以预先确定的目标强度进行为期四周的12次间歇训练。根据预先定义的规则，在每个连续队列中，每个阶层的强度将增加，直到达到最大安全和可耐受强度，这取决于剂量限制事件和不良事件的发生。剂量限制事件被定义为过度训练的症状，包括疼痛和无法进行常规活动。研究结果：在中低运动能力的中风幸存者中，CRF训练的最大安全和可耐受强度。讨论：本研究是CRF培训干预系统开发的第一步。我们认为，类似的剂量范围设计可能有助于在不同研究人群中开发其他康复干预措施。

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