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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Multiple Border-Zone Infarcts Triggered by Influenza A Virus Infection in a Patient With Cerebral Autosomal Dominant Arteriopathy Presenting With Subcortical Infarcts and Leukoencephalopathy
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Multiple Border-Zone Infarcts Triggered by Influenza A Virus Infection in a Patient With Cerebral Autosomal Dominant Arteriopathy Presenting With Subcortical Infarcts and Leukoencephalopathy

机译：患有脑常染色体显性动脉病患者的患者患者触发的多个边界区梗塞，患有皮下梗死和白细胞病

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摘要

Patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) can develop multiple border-zone infarcts due to hypotension, hypovolemia, or surgery. We report the case of a 41-year-old woman with CADASIL who developed multiple border-zone infarcts due to influenza A virus infection. The patient had no apparent history or episode of stroke or altered consciousness following the onset of respiratory symptoms, which were due to the influenza A infection. Diffusion-weighted magnetic resonance images of the brain showed multiple acute-phase infarcts in border-zone areas of both cerebral hemispheres and the corpus callosum; fluid-attenuated inversion-recovery magnetic resonance images showed increased signal in the subcortical areas of both temporal poles. Gene analysis identified a heterozygous mutation c.160C>T in exon 2 of the NOTCH3 gene (p.Arg54Cys). A diagnosis of CADASIL was established. Our case demonstrates that infectious conditions such as influenza A can trigger multiple border-zone infarctions in patients with CADASIL.
机译：伴有皮质下梗死和白质脑病（CADASIL）的常染色体显性遗传性脑动脉病患者可因低血压、低血容量或手术而发展为多发性边缘区梗死。我们报告一例41岁女性CADASIL患者，她因a型流感病毒感染而发生多发性边界区梗死。该患者没有明显的中风病史或发作，也没有出现由甲型流感感染引起的呼吸道症状后意识改变。脑弥散加权磁共振成像显示大脑半球和胼胝体边缘区多发急性期梗死；液体衰减反转恢复磁共振图像显示双侧颞极皮质下区信号增强。基因分析发现NOTCH3基因（p.Arg54Cys）第2外显子中存在杂合突变c.160C>T。确诊为CADASIL。我们的病例表明，在CADASIL患者中，甲型流感等感染性疾病可引发多发性边界区梗死。

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