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首页> 外文期刊>Journal of studies on alcohol and drugs. >Cue Exposure Triggers Inhibitory Deficits in Individuals With Methamphetamine Use Disorder
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Cue Exposure Triggers Inhibitory Deficits in Individuals With Methamphetamine Use Disorder

机译：提示曝光触发甲基苯丙胺使用障碍的个体中的抑制性缺陷

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摘要

Objective: Inhibitory deficits contribute to impulsive drug-seeking behavior in individuals with methamphetamine use disorder (MUD). Whether abstinent individuals with MUD exhibit greater cognitive disinhibition when the suppressed response is associated with drug-related images is not fully known. This study evaluated the potency of drug-associated cue exposure in this process. Method: We recruited 54 abstinent men with MUD and 46 healthy control (HC) subjects to complete a novel go/no-go task in which drug-associated cues were presented in 240 trials. Results: Exposure to drug-associated cues, the numbers of commission errors increased significantly only in the abstinent MUD group (p < .001), and the abstinent MUD group produced higher levels of commission errors than the HC group (p = .009). When drug-associated cues were not available (in scrambled trials), the abstinent MUD group produced similar levels of commission errors when compared with the HC group (p = .336). The reaction times in drug cue exposure trials were longer than in scrambled trials across groups (p < .001), whereas the abstinent MUD group produced shorter reaction times than HCs, regardless of trial conditions (p = .004). Conclusions: The novel go/no-go task is a useful method for detecting impulsivity in abstinent individuals with MUD. Cue exposure triggers impairment of inhibitory control in individuals with MUD at abstinence.
机译：目的：抑制缺陷导致甲基苯丙胺使用障碍（MUD）患者的冲动性药物寻求行为。当被抑制的反应与药物相关图像相关时，患有MUD的禁欲个体是否表现出更大的认知去抑制尚不完全清楚。本研究评估了药物相关线索暴露在这一过程中的效力。方法：我们招募了54名患有MUD的戒断男性和46名健康对照（HC）受试者，完成一项新的go/no go任务，在240项试验中呈现药物相关线索。结果：暴露于药物相关线索下，仅在戒断泥组中，委员会错误的数量显著增加（p<0.001），而戒断泥组产生的委员会错误水平高于HC组（p=0.009）。当药物相关线索不可用时（在混乱试验中），与HC组相比，禁欲MUD组产生的佣金错误水平相似（p=0.336）。药物提示暴露试验中的反应时间比各组间的混乱试验中的反应时间长（p<0.001），而无论试验条件如何，戒断泥浆组的反应时间都比HCs组短（p=0.004）。结论：新的go/no go任务是一种有用的方法来检测患有MUD的戒断者的冲动性。线索暴露会导致在禁欲状态下患有MUD的个体的抑制性控制受损。

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    He Xi; Zhao Di; Zhang Mingming; Leng Yexi; He Weiqi;

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    Liaoning Normal Univ Res Ctr Brain &

    Cognit Neurosci Dalian 116029 Peoples R China;

    Shanghai Jiao Tong Univ Shanghai Mental Hlth Ctr Shanghai Key Lab Psychot Disorders Sch Med;

    Liaoning Normal Univ Res Ctr Brain &

    Cognit Neurosci Dalian 116029 Peoples R China;

    Liaoning Normal Univ Res Ctr Brain &

    Cognit Neurosci Dalian 116029 Peoples R China;

    Liaoning Normal Univ Res Ctr Brain &

    Cognit Neurosci Dalian 116029 Peoples R China;

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  • 正文语种 eng
  • 中图分类 药学;
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