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首页> 外文期刊>Journal of substance abuse treatment >Long-term functioning to provide empirical support for the clinical relevance of treatment outcomes for methamphetamine use disorders
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Long-term functioning to provide empirical support for the clinical relevance of treatment outcomes for methamphetamine use disorders

机译：长期发作，为甲基苯丙胺使用障碍治疗结果的临床相关性提供实证支持

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Background: Research has yet to empirically evaluate methamphetamine (MA) use outcome measures commonly used to indicate treatment success. Clinically meaningful outcomes must be associated with long-term functioning in important life domains. This study evaluated the association between different MA use outcomes and long-term life-functioning. Method: The data that this study used in its secondary analyses were pooled from two treatment trials for MA use disorders (n = 237). The study conducted multiple regression analyses (with multiple imputation for missing data) to determine the association of six within-treatment MA use outcome measures with problem severity in seven life domains and a proxy measure for overall functioning, measured with the Addiction Severity Index (ASI) and assessed at an 8-month follow-up. Results: The longest duration of abstinence (LDA) outcome achieved the most consistent performance, being associated with better scores in five of eight ASI outcomes (? ranging from -0.203 to -0.291; p < .01). The complete abstinence during treatment demonstrated the poorest performance and was not significantly associated with any of the ASI outcomes. All other MA use outcome measures were significantly (p < .01) associated with at least one ASI outcome. Conclusion: This study provides empirical support for the use of LDA as a clinically relevant indicator of treatment success for MA use disorders, while also indicating the limitations of using complete abstinence during treatment to determine treatment success. Based on these findings, providers and researchers should use LDA as a primary outcome for MA use disorder treatments and trials.
机译：背景：研究还没有对甲基苯丙胺（MA）使用结果进行实证评估，这些指标通常用于指示治疗成功。临床上有意义的结果必须与重要生活领域的长期功能相关。本研究评估了不同MA使用结果与长期生活功能之间的关联。方法：本研究在二次分析中使用的数据来自两个MA使用障碍治疗试验（n=237）。该研究进行了多元回归分析（对缺失数据进行多重插补），以确定六项治疗内MA使用结果指标与七个生活领域的问题严重程度的关联，以及一项总体功能的替代指标，用成瘾严重性指数（ASI）进行测量，并在8个月的随访中进行评估。结果：最长的禁欲时间（LDA）结果取得了最一致的表现，与八项ASI结果中的五项得分较高相关（范围从-0.203到-0.291；p<0.01）。治疗期间的完全禁欲表现最差，与ASI的任何结果均无显著相关性。所有其他MA使用结果指标均与至少一项ASI结果显著相关（p<0.01）。结论：本研究为LDA作为MA使用障碍治疗成功的临床相关指标提供了实证支持，同时也表明了在治疗期间使用完全禁欲来确定治疗成功的局限性。基于这些发现，提供者和研究人员应该将LDA作为MA使用障碍治疗和试验的主要结果。

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