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Updates on Therapeutic Advancements in Relapsed or Refractory Multiple Myeloma: Highlights From SOHO 2020

机译:复发或难治性多发性骨髓瘤的治疗进步的更新:来自SOHO 2020的亮点

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Cecent therapeutic advancements in early relapsed/refractory (R/R) multiple myeloma (MM) have led to several clinical trials and U.S. Food & Drug Administration (FDA) approvals. Although patient outcomes have improved due to the adoption of immunomodulatory drugs, proteasome inhibitors, and novel agents, the natural history of the disease predicts relapses will occur, necessitating subsequent lines of therapy. With the increasing use of frontline agents, such as lenalidomide (Revlimid) and bortezomib (Velcade), there is an emerging need for novel drug combinations with different mechanisms of action for relapsed/refractory disease where three-drug regimens are preferable.
机译:Cecent在早期复发/难治性(R/R)多发性骨髓瘤(MM)方面的治疗进展已导致多项临床试验和美国食品和药物管理局(FDA)的批准。尽管由于采用了免疫调节药物、蛋白酶体抑制剂和新型药物,患者的预后有所改善,但疾病的自然史预测会出现复发,因此需要后续的治疗。随着来那度胺(Revlimid)和硼替佐米(Velcade)等一线药物的使用日益增多,对于复发/难治性疾病,新的药物组合具有不同的作用机制,其中三种药物方案更可取。

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