• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of the mechanical behavior of biomedical materials >Osseointegration evaluation of UHMWPE and PEEK-based scaffolds with BMP-2 using model of critical-size cranial defect in mice and push-out test
【24h】

Osseointegration evaluation of UHMWPE and PEEK-based scaffolds with BMP-2 using model of critical-size cranial defect in mice and push-out test

机译：使用小鼠临界大小颅骨缺陷模型与BMP-2对uhmWPE和PEEK的支架的骨整合评估，用小鼠和推出试验

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

It the present study the push-out mechanical test was adopted for mouse model of implantation in critical-size cranial defects to evaluate the effectiveness of implant-skull fusion. As implants, disks of porous ultra-high molecular weight polyethylene (UHMWPE) and polyetheretherketone (PEEK) with hydroxylapatite (HA) with and without loading of recombinant bone morphogenetic protein-2 (BMP-2) were used. Implantation results were evaluated using histology and micro-computed tomography (micro-CT). In the case of both UHMWPE/HA and PEEK/HA, BMP-2 loading resulted in a significant increase in the amount of bone tissue in the implantation area, especially at the edges of the defect, and an increase in the value of BV/TV (bone volume/tissue volume) during micro-CT. There was a high correlation of BV/TV values with the maximum load and elastic modulus measured during the puch-out test. The maximum load values showed good convergence within the groups and are comparable to the maximum load values obtained by other authors in the rat model of implantation in critical-size cranial defects. An adapted push-out test can be used to evaluate the quality of osseointegration of the implanted materials.
机译：本研究采用小鼠临界大小颅骨缺损植入模型，通过推出力学试验来评价植入颅骨融合的效果。作为植入物，使用多孔超高分子量聚乙烯（UHMWPE）和聚醚醚酮（PEEK）与羟基磷灰石（HA）制成的圆盘，在有或没有装载重组骨形态发生蛋白-2（BMP-2）的情况下使用。植入结果通过组织学和显微计算机断层扫描（micro CT）进行评估。在UHMWPE/HA和PEEK/HA的情况下，BMP-2负载导致植入区域的骨组织数量显著增加，尤其是在缺损边缘，并且在微CT期间BV/TV（骨体积/组织体积）值增加。BV/TV值与puch out试验期间测得的最大载荷和弹性模量高度相关。最大载荷值在各组内表现出良好的收敛性，并与其他作者在植入临界尺寸颅骨缺损的大鼠模型中获得的最大载荷值相当。适应性推出试验可用于评估植入材料的骨整合质量。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号