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首页> 外文期刊>Journal of the mechanical behavior of biomedical materials >The effect of albumin and gamma-globulin on synovial fluid lubrication: Implication for knee joint replacements
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The effect of albumin and gamma-globulin on synovial fluid lubrication: Implication for knee joint replacements

机译：白蛋白和γ-球蛋白对滑膜流体润滑的影响：膝关节置换的含义

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摘要

Total knee arthroplasty has become a routine procedure for patients suffering from joint diseases. Although the number of operations continuously increases, a limited service-life of implants represents a persisting challenge for scientists. Understanding of lubrication may help to suitably explain tribological processes on the way to replacements that become durable well into the third decade of service. The aim of the present study is to assess the formation of protein lubricating film in the knee implant. A developed knee simulator was used to observe the contact of real femoral and transparent polymer tibial component using fluorescent microscopy. The contact was lubricated by various protein solutions with attention to the behaviour of albumin and gamma-globulin. In order to suitably mimic a human synovial fluid, hyaluronic acid and phospholipids were subsequently added to the solutions. Further, the change in shape and the migration of the contact zone were studied. The results showed considerable appearance differences of the contact over the swing phase of the simplified gait cycle. Regarding film formation, a strong interaction of the various molecules of synovial fluid was observed. It was found that the thickness of the lubricating layer stabilizes within around 50 s. Throughout the contact zone, protein agglomerations were present and could be clearly visualised using the applied optical technique.
机译：全膝关节置换术已成为关节疾病患者的常规手术。尽管手术数量不断增加，但植入物的有限使用寿命对科学家来说是一个持续的挑战。对润滑的理解可能有助于恰当地解释更换过程中的摩擦学过程，这些过程在使用第三个十年后变得很耐用。本研究的目的是评估膝关节植入物中蛋白质润滑膜的形成。使用开发的膝关节模拟器，使用荧光显微镜观察真实股骨和透明聚合物胫骨组件的接触。接触由各种蛋白质溶液润滑，注意白蛋白和丙种球蛋白的行为。为了适当地模拟人类滑液，随后将透明质酸和磷脂添加到溶液中。此外，还研究了接触带的形状变化和迁移。结果显示，在简化步态周期的摆动阶段，接触的外观存在相当大的差异。关于成膜，观察到滑液中各种分子之间的强烈相互作用。研究发现，润滑层的厚度在大约50秒内稳定下来。在整个接触区，存在蛋白质聚集，并且可以使用应用的光学技术清晰地显示出来。

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