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首页> 外文期刊>Journal of the Science of Food and Agriculture >Neuroprotective effects of mango cv. 'Ataulfo' peel and pulp against oxidative stress in streptozotocin-induced diabetic rats
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Neuroprotective effects of mango cv. 'Ataulfo' peel and pulp against oxidative stress in streptozotocin-induced diabetic rats

机译：芒果CV的神经保护作用。 'Ataulfo'剥皮和纸浆对链脲佐菌素诱导的糖尿病大鼠氧化胁迫

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BACKGROUND Oxidative stress has been implicated in the pathogenesis and progression of diabetes mellitus. Both can damage the brain. Mango and its by-products are sources of bioactive compounds with antioxidant properties. We hypothesized that mango cv. 'Ataulfo' peel and pulp mitigate oxidative stress in the brain of streptozotocin-induced diabetic rats. RESULTS Twenty-four male Wistar rats were divided into four groups: control, untreated diabetic (UD), diabetic treated with a mango-supplemented diet (MTD), and diabetic pretreated with a mango-supplemented diet (MPD). The rats were fed the different diets for 4 weeks after diabetes induction (MTD), or 2 weeks before and 4 weeks after induction (MPD). After the intervention, serum and brain (cerebellum and cortex) were collected to evaluate gene expression, enzyme activity, and redox biomarkers. Superoxide dismutase 2 (SOD2) expression increased in the cortex of the MTD group, whereas glutathione-S-transferase p1 (GSTp1) expression was higher in the cortex of the MTD group, and cortex and cerebellum of the MPD group. SOD1 activity was higher in the cerebellum and cortex of all diabetic groups, whereas GST activity increased in the cerebellum and cortex of the MPD group. Lipid peroxidation increased in the cerebellum and cortex of the UD group; however, a mango-supplemented diet prevented this increase in both regions, while also mitigating polyphagia and weight loss, and maintaining stable glycemia in diabetic rats. CONCLUSION We propose that mango exerts potent neuroprotective properties against diabetes-induced oxidative stress. It can be an alternative to prevent and treat biochemical alterations caused by diabetes. (c) 2020 Society of Chemical Industry
机译：背景氧化应激与糖尿病的发病机制和进展有关。两者都会损害大脑。芒果及其副产品是具有抗氧化特性的生物活性化合物的来源。我们假设芒果阿托福果皮和果肉减轻链脲佐菌素诱导的糖尿病大鼠大脑中的氧化应激。结果24只雄性Wistar大鼠分为4组：对照组、未治疗糖尿病组（UD）、添加芒果的糖尿病组（MTD）和添加芒果的糖尿病组（MPD）。在糖尿病诱导（MTD）后4周，或诱导前2周和诱导后4周，给大鼠喂食不同的饮食。干预后，收集血清和大脑（小脑和皮质）以评估基因表达、酶活性和氧化还原生物标记物。MTD组皮质中超氧化物歧化酶2（SOD2）的表达增加，而谷胱甘肽-S-转移酶p1（GSTp1）的表达在MTD组皮质以及MPD组皮质和小脑中更高。所有糖尿病组的小脑和皮质SOD1活性均较高，而MPD组的小脑和皮质GST活性升高。UD组小脑和皮质脂质过氧化增加；然而，补充芒果的饮食阻止了这两个区域的这种增加，同时也减轻了糖尿病大鼠的多食症和体重减轻，并维持稳定的血糖。结论我们认为芒果对糖尿病诱导的氧化应激具有强大的神经保护作用。它可以作为预防和治疗糖尿病引起的生化改变的替代品。（c） 2020年化学工业学会

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