Modeling the effect of immunotherapies on human castration-resistant prostate cancer

Coletti Roberta; Pugliese Andrea; Marchetti Luca

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Modeling the effect of immunotherapies on human castration-resistant prostate cancer

机译：造型免疫治疗对抗抗抗原前列腺癌的影响

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In this paper we analyze the potential effect of immunotherapies on castration-resistant form of human Prostate Cancer (PCa). In particular, we examine the potential effect of the dendritic vaccine sipuleucel-T, the only currently available immunotherapy option for advanced PCa, and of ipilimumab, a drug targeting the Cytotoxic T-Lymphocyte Antigen 4 (CTLA4), exposed on the CTLs membrane, currently under Phase II clinical trial. The model, building on the one by Rutter and Kuang, includes different types of immune cells and interactions and is parameterized on available data.

机译：在本文中，我们分析了免疫疗法对人类前列腺癌（PCa）抗去势形式的潜在影响。特别是，我们检查了树突状疫苗sipuleucel-T（目前唯一可用的晚期PCa免疫治疗选择）和伊普利单抗（一种靶向细胞毒性T淋巴细胞抗原4（CTLA4）的药物）的潜在效果，该药物暴露在CTLs膜上，目前正在进行II期临床试验。该模型以Rutter和Kuang的模型为基础，包括不同类型的免疫细胞和相互作用，并根据可用数据进行参数化。

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来源
《Journal of Theoretical Biology》 |2021年第1期|共18页
作者
Coletti Roberta; Pugliese Andrea; Marchetti Luca;
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作者单位

Univ Trento Dept Math I-38123 Trento Italy;

Univ Trento Dept Math I-38123 Trento Italy;

Univ Trento Ctr Computat &

Syst Biol Fdn Microsoft Res I-38068 Rovereto Italy;

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原文格式 PDF
正文语种 eng
中图分类普通生物学;
关键词
Prostate cancer; Mathematical modeling; ODE system; Steady state analysis; Computational biology; QSS approximation; Immunotherapy; Anti-CTLA4; Dendritic vaccine; Ipilimumab; Sipuleucel-T;

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专利

1. Radioiodine therapy for castration-resistant prostate cancer following prostate-specific membrane antigen promoter-mediated transfer of the human sodium iodide symporter [J] . Xiao-Feng Gao, Tie Zhou, Guang-Hua Chen, 亚洲男性学杂志（英文版） . 2014,第001期
2. Method of directly defining the inverse mapping applied to prostate cancer immunotherapy --Mathematical model [J] . Ophir Nave, Miriam Elbaz 生物数学学报：英文版 . 2018,第005期
3. Understanding prostate-speciifc antigen dynamics in monitoring metastatic castration-resistant prostate cancer:implications for clinical practice [J] . Atsushi Mizokami, Kouji Izumi, Hiroyuki Konaka, 亚洲男性学杂志（英文版） . 2017,第002期
4. Human prostate cancer heterotransplants： a review on this experimental model [J] . Lluis A. Lopez-Barcons 亚洲男性学杂志：英文版 . 2010,第004期
5. Combined immunotherapy with granulocyte-macrophage colony-stimulating factor-transduced allogeneic prostate cancer cells and ipilimumab in patients with metastatic castration-resistant prostate cancer: A phase 1 dose-escalation trial [J] . VandenEertweghA.J.M., VersluisJ., VandenBergH.P., The lancet oncology . 2012,第5期

机译：转移性去势抵抗性前列腺癌患者的联合免疫疗法与粒细胞巨噬细胞集落刺激因子转导的异基因前列腺癌细胞和伊匹单抗的联合治疗
6. Erratum: Interdisciplinary critique of sipuleucel-T as immunotherapy in castration-resistant prostate cancer (Journal of the National Cancer Institute (2012) 104:4 (273-279)) [J] . HuberM.L., HaynesL., ParkerC., Journal of the National Cancer Institute . 2014,第4期

机译：勘误：跨学科批评sipuleucel-T作为去势抵抗性前列腺癌的免疫疗法（美国国家癌症研究所杂志（2012）104：4（273-279））
7. Defining a Population of Stem-like Human Prostate Cancer Cells That Can Generate and Propagate Castration-Resistant Prostate Cancer [J] . Chen Xin, Li Qiuhui, Liu Xin, Clinical cancer research: an official journal of the American Association for Cancer Research . 2016,第17期

机译：定义可以产生和传播去势抵抗性前列腺癌的干状人类前列腺癌细胞群
8. A MATHEMATICAL MODEL FOR THE IMMUNOTHERAPY OF ADVANCED PROSTATE CANCER [C] . TRAVIS PORTZ, YANG KUANG International Symposium on Mathematical and Computational Biology . 2013

机译：一种晚期前列腺癌免疫疗法的数学模型
9. Studies on human prostate-specific antigen as a tumor antigen for the immunotherapy of prostate cancer in a mouse model. [D] . Willis, Richard Allen. 2002

机译：人类前列腺特异性抗原作为一种肿瘤抗原的免疫模型在小鼠模型中的研究。
10. Immunotherapy and Immunotherapy Combinations in Metastatic Castration-Resistant Prostate Cancer [O] . Dhruv Bansal, Melissa A. Reimers, Eric M. Knoche, 2021

机译：免疫疗法和免疫疗法组合在转移性阉割抗阉割前列腺癌中
11. MK591, a second generation leukotriene biosynthesis inhibitor, prevents invasion and induces apoptosis in the bone-invading C4-2B human prostate cancer cells: implications for the treatment of castration-resistant, bone-metastatic prostate cancer. [O] . Sivalokanathan Sarveswaran, Ritisha Ghosh, Shravan Morisetty, 2015

机译：mK591是第二代白三烯生物合成抑制剂，可阻止侵入并诱导骨侵袭C4-2B人前列腺癌细胞的凋亡：对抗去势，骨转移性前列腺癌的治疗意义。
12. Developing Models to Facilitate the Appropriate Selection and Effective Targeting of Candidate Antigens for Specific Cellular Immunotherapy of Prostate Cancer [R] . Greenberg, P. D. 2006

机译：开发模型以促进适当选择和有效靶向候选抗原用于前列腺癌的特异性细胞免疫治疗

Modeling the effect of immunotherapies on human castration-resistant prostate cancer

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