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首页> 外文期刊>Journal of Veterinary Diagnostic Investigation >Serum fibroblast growth factor 23 (FGF-23): associations with hyperphosphatemia and clinical staging of feline chronic kidney disease
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Serum fibroblast growth factor 23 (FGF-23): associations with hyperphosphatemia and clinical staging of feline chronic kidney disease

机译：血清成纤维细胞生长因子23（FGF-23）：具有高磷脂血症的关联和猫科动物慢性肾病的临床分期

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Fibroblast growth factor 23 (FGF-23) is an independent monitor of the progression of chronic kidney disease (CKD) in human medicine, and FGF-23 may have value as a biomarker in feline CKD. We evaluated the relationship between serum FGF-23 and CKD stages, and the effect of age on FGF-23 in normal cats. We measured FGF-23 and intact parathyroid hormone (iPTH) concentrations by ELISA, with intra- and inter-assay CVs <= 15%. The percentage recovery of FGF-23 and iPTH remained stable for up to 7 d in samples stored at -20 degrees C and -80 degrees C. We measured FGF-23 in 304 cats, among which 196 were diagnosed with CKD. The 108 clinically healthy cats were divided into 5 subgroups based on growth stage (0-2 y, 3-6 y, 7-10 y, 11-14 y, >= 15 y). No statistical difference was found in FGF-23 among age groups (p = 0.15) or by sex in healthy subjects. Using the International Renal Interest Society guideline, 34 cats were defined as CKD stage 1, 74 stage 2, 51 stage 3, and 37 stage 4. FGF-23 was higher in cats in all CKD stages than in controls. Higher serum phosphorus was observed in stage 3 (p = 0.04) and 4 (p < 0.01) compared to controls. iPTH increased as CKD progressed. Pearson analysis indicated a positive linear relationship between FGF-23 and iPTH (control: r = 0.70, p < 0.01; CKD: r = 0.46, p = 0.02). FGF-23 may be a useful biomarker of feline CKD and may precede hyperphosphatemia in advanced feline CKD.
机译：在人类医学中，成纤维细胞生长因子23（FGF-23）是慢性肾脏疾病（CKD）进展的独立监测者，FGF-23可能作为猫CKD的生物标志物具有价值。我们评估了正常猫血清FGF-23与CKD分期之间的关系，以及年龄对FGF-23的影响。我们通过ELISA测定FGF-23和完整甲状旁腺激素（iPTH）浓度，分析内和分析间CVs≤15%。在-20摄氏度和-80摄氏度下储存的样本中，FGF-23和iPTH的回收率在长达7天的时间内保持稳定。我们在304只猫中测量了FGF-23，其中196只被诊断为CKD。108只临床健康猫根据生长阶段分为5个亚组（0-2岁、3-6岁、7-10岁、11-14岁、>=15岁）。FGF-23在各年龄组（p=0.15）之间或健康受试者的性别之间没有发现统计学差异。根据国际肾脏利益协会指南，34只猫被定义为CKD 1期、74只2期、51只3期和37只4期。在所有CKD阶段，猫的FGF-23都高于对照组。与对照组相比，在第3阶段（p=0.04）和第4阶段（p<0.01）观察到较高的血清磷。随着CKD的进展，iPTH增加。Pearson分析表明FGF-23和iPTH之间存在正线性关系（对照组：r=0.70，p<0.01；CKD:r=0.46，p=0.02）。FGF-23可能是一种有用的猫CKD生物标志物，并可能先于晚期猫CKD的高磷血症。

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