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首页> 外文期刊>Journal of women’s health >Duration of Reproductive Years and the Risk of Cardiovascular and Cerebrovascular Events in Older Women: Insights from the National Health and Nutrition Examination Survey
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Duration of Reproductive Years and the Risk of Cardiovascular and Cerebrovascular Events in Older Women: Insights from the National Health and Nutrition Examination Survey

机译：生殖年的持续时间以及老年女性心血管和脑血管血管事件的风险：来自国家卫生和营养考试调查的见解

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Background: Studies have shown conflicting information regarding the association between the age at menarche and/or menopause and cardiovascular and cerebrovascular diseases in older women. This study aimed to determine whether a longer duration of reproductive years in older women in the U.S. population was associated with a lower risk of cardiovascular and cerebrovascular diseases. Materials and Methods: Women 60 years who participated in the National Health and Nutrition Examination Survey from 2007 to 2012 were included. Subjects provided information about the age of menarche and menopause along with the presence/absence of cardiovascular and cerebrovascular diseases. Participants were categorized into either a longer reproductive duration group (>30 years) or shorter reproductive duration group (30 years). Subgroup analysis for each 5-year increment in the longer reproductive duration group was conducted. Relative risk (RR) regression was performed using a generalized linear model adjusting for several confounding factors. Results: 3081 participants were included in the analysis. A longer duration of reproductive years was associated with a lower risk of cardiovascular and cerebrovascular diseases, compared with a shorter duration (RR 0.70, 95% confidence interval [CI] 0.53-0.92). This association was due to a reduction in the risk of stroke (RR 0.53, 95% CI 0.34-0.88) and angina (RR 0.57, 95% CI 0.34-0.97). A 1 year increase in the reproductive duration was associated with a 3% reduction in the risk of events (RR 0.97, 95% CI 0.95-0.99). Conclusion: Among women 60 years, a longer duration of reproductive years was associated with lower risk of cardiovascular and cerebrovascular diseases. This association was mainly due to a reduction in the risk of stroke and angina.
机译：背景：研究表明，关于老年女性月经初潮和/或绝经年龄与心脑血管疾病之间的关联，存在相互矛盾的信息。这项研究的目的是确定美国老年女性生育年限较长是否与心脑血管疾病风险较低有关。材料和方法：纳入2007年至2012年参加全国健康和营养检查调查的60岁女性。受试者提供了有关月经初潮和绝经年龄以及是否存在心脑血管疾病的信息。参与者被分为生育期较长的组（>30年）或生育期较短的组（30年）。对生育期较长组每增加5年进行亚组分析。相对风险（RR）回归是使用一个广义线性模型进行的，该模型调整了几个混杂因素。结果：3081名参与者被纳入分析。生育年限越长，心脑血管疾病的风险越低，而生育年限越短（RR 0.70，95%可信区间[CI]0.53-0.92）。这种关联是由于中风风险（RR 0.53，95%可信区间0.34-0.88）和心绞痛风险（RR 0.57，95%可信区间0.34-0.97）降低所致。生育期延长1年与事件风险降低3%相关（RR 0.97，95%可信区间0.95-0.99）。结论：在60岁的女性中，生育年限越长，患心脑血管疾病的风险越低。这种联系主要是由于中风和心绞痛的风险降低。

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